Linked Life Data

11692274

Source:http://linkedlifedata.com/resource/pubmed/id/11692274

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pubmed-article:11692274pubmed:abstractTextRecent work has indicated that smooth muscle force production may be influenced by pathways not dependent upon the Ca2+-calmodulin phosphorylation of light chains. Few studies, however, have examined the importance of these pathways in intact muscles that contract phasically rather than tonically. Therefore, to determine whether the Ca2+-independent Rho-A and associated kinase (ROK) pathway can affect contractions of the intact human myometrium, we used Y-27632 to inhibit ROK. Three types of contractile activity were examined: spontaneous and those elicited by oxytocin and by depolarisation by high K+. Y-27632 decreased force significantly under all three conditions, without changing intracellular [Ca2+]. However, the effects on force were only large when the uterus was producing force tonically rather than phasically. This suggests that the Rho-A-ROK pathway may not be a potent modulator of force in the human myometrium under physiological conditions.lld:pubmed
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pubmed-article:11692274pubmed:articleTitleThe effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometrium.lld:pubmed
pubmed-article:11692274pubmed:affiliationDepartment of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.lld:pubmed
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