| pubmed-article:11691831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C1514721 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:11691831 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:11691831 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11691831 | pubmed:dateCreated | 2001-11-5 | lld:pubmed |
| pubmed-article:11691831 | pubmed:abstractText | Proteolytic maturation of proBMP-4 is required to generate an active signaling molecule. We show that proBMP-4 is cleaved by furin in a sequential manner. Cleavage at a consensus furin site adjacent to the mature ligand domain allows for subsequent cleavage at an upstream nonconsensus furin site within the prodomain. BMP-4 synthesized from precursor in which the upstream site is noncleavable is less active, signals at a shorter range, and accumulates at lower levels than does BMP-4 cleaved from native precursor. Conversely, BMP-4 cleaved from precursor in which both sites are rapidly cleaved is more active and signals over a greater range. Differential use of the upstream cleavage site could provide for tissue-specific regulation of BMP-4 activity and signaling range. | lld:pubmed |
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| pubmed-article:11691831 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11691831 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11691831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11691831 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11691831 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:11691831 | pubmed:author | pubmed-author:NakayamaTT | lld:pubmed |
| pubmed-article:11691831 | pubmed:author | pubmed-author:ThomasGG | lld:pubmed |
| pubmed-article:11691831 | pubmed:author | pubmed-author:JeanFF | lld:pubmed |
| pubmed-article:11691831 | pubmed:author | pubmed-author:BergLL | lld:pubmed |
| pubmed-article:11691831 | pubmed:author | pubmed-author:CuiYY | lld:pubmed |
| pubmed-article:11691831 | pubmed:author | pubmed-author:ChristianJ... | lld:pubmed |
| pubmed-article:11691831 | pubmed:author | pubmed-author:HackenmillerR... | lld:pubmed |
| pubmed-article:11691831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11691831 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11691831 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:11691831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11691831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11691831 | pubmed:pagination | 2797-802 | lld:pubmed |
| pubmed-article:11691831 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11691831 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11691831 | pubmed:articleTitle | The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. | lld:pubmed |
| pubmed-article:11691831 | pubmed:affiliation | Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA. | lld:pubmed |
| pubmed-article:11691831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11691831 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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