| pubmed-article:11689882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11689882 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:11689882 | lifeskim:mentions | umls-concept:C0061465 | lld:lifeskim |
| pubmed-article:11689882 | lifeskim:mentions | umls-concept:C0282056 | lld:lifeskim |
| pubmed-article:11689882 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:11689882 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11689882 | pubmed:dateCreated | 2001-11-5 | lld:pubmed |
| pubmed-article:11689882 | pubmed:abstractText | In systemic lupus erythematosus, antibodies against double-stranded DNA are a major contributor to renal disease. We have previously demonstrated that the pentapeptide Asp/Glu-Trp-Asp/Glu-Tyr-Ser/Gly is a molecular mimic of double-stranded DNA. This sequence is also present in the extracellular domain of murine and human NMDA (N-methyl-D-aspartate) receptor subunits NR2a and NR2b. Here we show that the NR2 receptor is recognized by both murine and human anti-DNA antibodies. Moreover, anti-DNA antibodies with this cross-reactivity mediate apoptotic death of neurons in vivo and in vitro. Finally, we show that the cerebrospinal fluid of a patient with systemic lupus erythematosus contains these antibodies and also mediates neuronal death via an apoptotic pathway. These observations indicate that lupus antibodies cross-react with DNA and NMDA receptors, gain access to cerebrospinal fluid and may mediate non-thrombotic and non-vasculitic abnormalities of the central nervous system. | lld:pubmed |
| pubmed-article:11689882 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689882 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11689882 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689882 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11689882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689882 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689882 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11689882 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11689882 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:11689882 | pubmed:author | pubmed-author:HSUF JFJ | lld:pubmed |
| pubmed-article:11689882 | pubmed:author | pubmed-author:HardinJ AJA | lld:pubmed |
| pubmed-article:11689882 | pubmed:author | pubmed-author:VolpeB TBT | lld:pubmed |
| pubmed-article:11689882 | pubmed:author | pubmed-author:DiamondBB | lld:pubmed |
| pubmed-article:11689882 | pubmed:author | pubmed-author:DeGiorgioL... | lld:pubmed |
| pubmed-article:11689882 | pubmed:author | pubmed-author:KonstantinovK... | lld:pubmed |
| pubmed-article:11689882 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11689882 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:11689882 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11689882 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11689882 | pubmed:pagination | 1189-93 | lld:pubmed |
| pubmed-article:11689882 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11689882 | pubmed:meshHeading | pubmed-meshheading:11689882... | lld:pubmed |
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| pubmed-article:11689882 | pubmed:meshHeading | pubmed-meshheading:11689882... | lld:pubmed |
| pubmed-article:11689882 | pubmed:meshHeading | pubmed-meshheading:11689882... | lld:pubmed |
| pubmed-article:11689882 | pubmed:meshHeading | pubmed-meshheading:11689882... | lld:pubmed |
| pubmed-article:11689882 | pubmed:meshHeading | pubmed-meshheading:11689882... | lld:pubmed |
| pubmed-article:11689882 | pubmed:meshHeading | pubmed-meshheading:11689882... | lld:pubmed |
| pubmed-article:11689882 | pubmed:meshHeading | pubmed-meshheading:11689882... | lld:pubmed |
| pubmed-article:11689882 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11689882 | pubmed:articleTitle | A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. | lld:pubmed |
| pubmed-article:11689882 | pubmed:affiliation | Department of Neurology & Neuroscience, The Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, New York, USA. | lld:pubmed |
| pubmed-article:11689882 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11689882 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11689882 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11689882 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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