| pubmed-article:11689622 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0023978 | lld:lifeskim |
| pubmed-article:11689622 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11689622 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:11689622 | pubmed:dateCreated | 2001-11-5 | lld:pubmed |
| pubmed-article:11689622 | pubmed:abstractText | The role of NF-kappaB in the reactivation of human immunodeficiency virus (HIV) from latency in CD4 T lymphocytes is well documented. However, its role in driving HIV transcription in human macrophages, which contain a constitutive nuclear pool of NF-kappaB, is less well understood. In this study we have investigated the role that the constitutive pool of NF-kappaB and the NF-kappaB cis-acting motifs of the HIV long terminal repeat (LTR) play in regulating HIV transcription in human monocytic cells and primary macrophages. Inhibition of the constitutive nuclear pool of NF-kappaB (RelA and RelB) in the promonocytic U937 cell line using dominant-negative IkappaBalpha significantly decreases HIV replication. Moreover, it is demonstrated that in the differentiated monocytic cell line THP1, which contains a constitutive nuclear pool of NF-kappaB (RelB),an HIV provirus containing mutations of the kappaB cis-acting sites in the LTR is transcriptionally impaired. Reduction of the constitutive pool of NF-kappaB in human macrophages by an adenovirus vector expressing a dominant-negative IkappaBalpha also reduces HIV transcription. Lastly, mutation of the NF-kappaB cis-acting sites in the LTR of an R5 HIV provirus completely abrogates the first cycle of HIV transcription. These studies indicate that the cis-acting NF-kappaB motifs of the HIV LTR are critical in initiating HIV transcription in human macrophages and suggest that the constitutive nuclear pool of NF-kappaB is important in regulating HIV transcription in these cells. | lld:pubmed |
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| pubmed-article:11689622 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11689622 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689622 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11689622 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11689622 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11689622 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11689622 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11689622 | pubmed:author | pubmed-author:PayaC VCV | lld:pubmed |
| pubmed-article:11689622 | pubmed:author | pubmed-author:BUKAMM | lld:pubmed |
| pubmed-article:11689622 | pubmed:author | pubmed-author:BrenG DGD | lld:pubmed |
| pubmed-article:11689622 | pubmed:author | pubmed-author:SolanN JNJ | lld:pubmed |
| pubmed-article:11689622 | pubmed:author | pubmed-author:CarmonaE MEM | lld:pubmed |
| pubmed-article:11689622 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11689622 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:11689622 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11689622 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11689622 | pubmed:pagination | 11408-16 | lld:pubmed |
| pubmed-article:11689622 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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