| pubmed-article:11687611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11687611 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:11687611 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:11687611 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:11687611 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:11687611 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:11687611 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:11687611 | lifeskim:mentions | umls-concept:C1512900 | lld:lifeskim |
| pubmed-article:11687611 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:11687611 | pubmed:dateCreated | 2001-11-7 | lld:pubmed |
| pubmed-article:11687611 | pubmed:abstractText | The risks and benefits of structured treatment interruption (STI) in HIV-1-infected subjects are not fully understood. A pilot study was performed to compare STI with continuous highly active antiretroviral therapy (HAART) in chronic HIV-1-infected subjects with HIV-1 plasma RNA levels (VL) <400 copies per ml and CD4(+) T cells >400 per microl. CD4(+) T cells, VL, HIV-1-specific neutralizing antibodies, and IFN-gamma-producing HIV-1-specific CD8(+) and CD4(+) T cells were measured in all subjects. STIs of 1-month duration separated by 1 month of HAART, before a final 3-month STI, resulted in augmented CD8(+) T cell responses in all eight STI subjects (P = 0.003), maintained while on HAART up to 22 weeks after STI, and augmented neutralization titers to autologous HIV-1 isolate in one of eight subjects. However, significant decline of CD4(+) T cell count from pre-STI level, and VL rebound to pre-HAART baseline, occurred during STI (P = 0.001 and 0.34, respectively). CD4(+) T cell counts were regained on return to HAART. Control subjects (n = 4) maintained VL <400 copies per ml and stable CD4(+) T cell counts, and showed no enhancement of antiviral CD8(+) T cell responses. Despite increases in antiviral immunity, no control of VL was observed. Future studies of STI should proceed with caution. | lld:pubmed |
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| pubmed-article:11687611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11687611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11687611 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11687611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11687611 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11687611 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:MontefioriDD | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:MirallesG DGD | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:NixonD FDF | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:Van LoonKK | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:BartlettJ AJA | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:BonhoefferSS | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:WellonsMM | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:OrtizG MGM | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:BrancatoJJ | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:HUQAA | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:ZinnR LRL | lld:pubmed |
| pubmed-article:11687611 | pubmed:author | pubmed-author:ClarksonD EDE | lld:pubmed |
| pubmed-article:11687611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11687611 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:11687611 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11687611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11687611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11687611 | pubmed:pagination | 13288-93 | lld:pubmed |
| pubmed-article:11687611 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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