pubmed-article:11687445 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0041296 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0337611 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0026912 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0037296 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0041289 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0872054 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0750540 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C0332185 | lld:lifeskim |
pubmed-article:11687445 | lifeskim:mentions | umls-concept:C1547564 | lld:lifeskim |
pubmed-article:11687445 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:11687445 | pubmed:dateCreated | 2001-11-5 | lld:pubmed |
pubmed-article:11687445 | pubmed:abstractText | The tuberculin skin test (TST) is used for the identification of latent tuberculosis (TB) infection (LTBI) but lacks specificity in Mycobacterium bovis BCG-vaccinated individuals, who constitute an increasing proportion of TB patients and their contacts from regions where TB is endemic. In previous studies, T-cell responses to ESAT-6 and CFP-10, M. tuberculosis-specific antigens that are absent from BCG, were sensitive and specific for detection of active TB. We studied 44 close contacts of a patient with smear-positive pulmonary TB and compared the standard screening procedure for LTBI by TST or chest radiographs with T-cell responses to M. tuberculosis-specific and nonspecific antigens. Peripheral blood mononuclear cells were cocultured with ESAT-6, CFP-10, TB10.4 (each as recombinant antigen and as a mixture of overlapping synthetic peptides), M. tuberculosis sonicate, purified protein derivative (PPD), and short-term culture filtrate, using gamma interferon production as the response measure. LTBI screening was by TST in 36 participants and by chest radiographs in 8 persons. Nineteen contacts were categorized as TST negative, 12 were categorized as TST positive, and 5 had indeterminate TST results. Recombinant antigens and peptide mixtures gave similar results. Responses to TB10.4 were neither sensitive nor specific for LTBI. T-cell responses to ESAT-6 and CFP-10 were less sensitive for detection of LTBI than those to PPD (67 versus 100%) but considerably more specific (100 versus 72%). The specificity of the TST or in vitro responses to PPD will be even less when the proportion of BCG-vaccinated persons among TB contacts evaluated for LTBI increases. | lld:pubmed |
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pubmed-article:11687445 | pubmed:language | eng | lld:pubmed |
pubmed-article:11687445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11687445 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11687445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:11687445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11687445 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11687445 | pubmed:month | Nov | lld:pubmed |
pubmed-article:11687445 | pubmed:issn | 1071-412X | lld:pubmed |
pubmed-article:11687445 | pubmed:author | pubmed-author:AndersenPP | lld:pubmed |
pubmed-article:11687445 | pubmed:author | pubmed-author:de BoerKK | lld:pubmed |
pubmed-article:11687445 | pubmed:author | pubmed-author:GrootGG | lld:pubmed |
pubmed-article:11687445 | pubmed:author | pubmed-author:OttenhoffT... | lld:pubmed |
pubmed-article:11687445 | pubmed:author | pubmed-author:ArendS MSM | lld:pubmed |
pubmed-article:11687445 | pubmed:author | pubmed-author:van DisselJ... | lld:pubmed |
pubmed-article:11687445 | pubmed:author | pubmed-author:EngelhardA... | lld:pubmed |
pubmed-article:11687445 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11687445 | pubmed:volume | 8 | lld:pubmed |
pubmed-article:11687445 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11687445 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11687445 | pubmed:pagination | 1089-96 | lld:pubmed |
pubmed-article:11687445 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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