| pubmed-article:11681709 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C1705572 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0172537 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11681709 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11681709 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11681709 | pubmed:dateCreated | 2001-10-29 | lld:pubmed |
| pubmed-article:11681709 | pubmed:abstractText | The present study demonstrates alterations in the regulation of matrix metalloproteinase-2 (MMP-2) expression in response to insulin like growth factor-1 (IGF-1) in a H-ras transformed cell line, C3, which is capable of metastasis formation. These changes in MMP-2 expression in response to IGF-1 treatment did not occur in either non-transformed parental 10 T 1/2 cells or in H-ras transformed cells (NR3 cells) which are capable of benign tumour formation. IGF-1 treatment of C3 cells resulted in increased expression of MMP-2 gelatinolytic activity and increased expression of MMP-2 mRNA levels. The IGF-1 mediated alterations in MMP-2 mRNA levels were dependent upon de novo protein synthesis and independent of transcriptional events, but dependent upon post-transcriptional regulatory events. Most notably, IGF-1 can regulate MMP-2 mRNA expression in C3 cells through a mechanism involving MMP-2 message stabilization. This study demonstrates aspects of the temporal regulatory mechanisms of MMP-2 expression in response to insulin-like growth factor-1 in a H-ras transformed fibrosarcoma cell line capable of metastasis formation and thereby, provides further insight into the altered growth regulatory program associated with H-ras mediated cellular transformation and malignant progression. | lld:pubmed |
| pubmed-article:11681709 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11681709 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11681709 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11681709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11681709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11681709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11681709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11681709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11681709 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11681709 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11681709 | pubmed:issn | 0300-8177 | lld:pubmed |
| pubmed-article:11681709 | pubmed:author | pubmed-author:HurtaR ARA | lld:pubmed |
| pubmed-article:11681709 | pubmed:author | pubmed-author:YoonAA | lld:pubmed |
| pubmed-article:11681709 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11681709 | pubmed:volume | 223 | lld:pubmed |
| pubmed-article:11681709 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11681709 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11681709 | pubmed:pagination | 1-6 | lld:pubmed |
| pubmed-article:11681709 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
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| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
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| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
| pubmed-article:11681709 | pubmed:meshHeading | pubmed-meshheading:11681709... | lld:pubmed |
| pubmed-article:11681709 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11681709 | pubmed:articleTitle | Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells. | lld:pubmed |
| pubmed-article:11681709 | pubmed:affiliation | Department of Laboratory Medicine and Pathobiology, St. Michael 's Hospital and the University of Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:11681709 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11681709 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11681709 | lld:pubmed |
