| pubmed-article:11679418 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C0205093 | lld:lifeskim |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C0549255 | lld:lifeskim |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C0671870 | lld:lifeskim |
| pubmed-article:11679418 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:11679418 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11679418 | pubmed:dateCreated | 2001-10-26 | lld:pubmed |
| pubmed-article:11679418 | pubmed:abstractText | Falls in blood glucose induce hunger and initiate feeding. The lateral hypothalamic area (LHA) contains glucose-sensitive neurons (GSNs) and orexin neurons, both of which are stimulated by falling blood glucose and are implicated in hypoglycemia-induced feeding. We combined intracellular electrophysiological recording with fluorescein labeling of GSNs to determine their neuroanatomic and functional relationships with orexin neurons. Orexin A (1 micromol/l) caused a 500% increase (P < 0.01) in spontaneous firing rate and rapid and lasting depolarization that was tetrodotoxin-resistant and thus a direct postsynaptic effect. Orexin A altered the intrinsic neuronal properties of GSNs, consistent with increased excitability. Confocal microscopy showed that GSNs were intimately related to orexin neurons: orexin-immunoreactive axons were frequently entwined around GSN dendrites, establishing close and putatively synaptic contacts. Orexin-cell axons also passed in close proximity to glucose-responsive neurons, which are inhibited by low glucose, but orexin A caused smaller depolarization than on GSNs and only a 200% increase in spontaneous firing rate (P < 0.05 vs. GSN). We conclude that GSNs are specific target neurons for orexin A and suggest that they may mediate, at least in part, the acute appetite-stimulating effect of orexin A. Orexin neurons may regulate GSNs so as to control the onset and termination of hypoglycemia-induced feeding. | lld:pubmed |
| pubmed-article:11679418 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11679418 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679418 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11679418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679418 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679418 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11679418 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11679418 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:11679418 | pubmed:author | pubmed-author:WilliamsGG | lld:pubmed |
| pubmed-article:11679418 | pubmed:author | pubmed-author:MorrisRR | lld:pubmed |
| pubmed-article:11679418 | pubmed:author | pubmed-author:WhiteMM | lld:pubmed |
| pubmed-article:11679418 | pubmed:author | pubmed-author:LiuX HXH | lld:pubmed |
| pubmed-article:11679418 | pubmed:author | pubmed-author:SpillerDD | lld:pubmed |
| pubmed-article:11679418 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11679418 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:11679418 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11679418 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11679418 | pubmed:pagination | 2431-7 | lld:pubmed |
| pubmed-article:11679418 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:meshHeading | pubmed-meshheading:11679418... | lld:pubmed |
| pubmed-article:11679418 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11679418 | pubmed:articleTitle | Orexin a preferentially excites glucose-sensitive neurons in the lateral hypothalamus of the rat in vitro. | lld:pubmed |
| pubmed-article:11679418 | pubmed:affiliation | Diabetes and Endocrinology Research Group, Department of Medicine University of Liverpool, Liverpool, UK. | lld:pubmed |
| pubmed-article:11679418 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11679418 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11679418 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11679418 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11679418 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11679418 | lld:pubmed |
