| pubmed-article:11602661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11602661 | lifeskim:mentions | umls-concept:C0009170 | lld:lifeskim |
| pubmed-article:11602661 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11602661 | lifeskim:mentions | umls-concept:C1512692 | lld:lifeskim |
| pubmed-article:11602661 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11602661 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:11602661 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:11602661 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11602661 | pubmed:dateCreated | 2001-10-16 | lld:pubmed |
| pubmed-article:11602661 | pubmed:abstractText | Genetic factors influence behavioral responses to cocaine as seen in comparisons of Lewis and Fischer 344 inbred rats. Lewis rats have lower D2-like receptor and Gi(alpha) levels in nucleus accumbens, an important area in behavioral responses to cocaine. This study assessed the effects of manipulating D2- and D1 levels pharmacologically in these strains. Experiment 1 investigated how the D2-like antagonist eticlopride (0.01-0.1 mg/kg), the D1-like antagonist SCH 23390 (0.005-0.05 mg/kg), the D2/D3 agonist quinpirole (0.001-0.1 mg/kg), and the partial D1 agonist SKF 38393 (0.1-10 mg/kg) affected responding for food under a fixed ratio 15 schedule. Quinpirole disrupted rates more readily in Lewis versus Fischer 344 rats. In experiment 2, the effects of these agents on cocaine discrimination (10 mg/kg) were examined. Quinpirole substituted and SCH 23390-attenuated cocaine discrimination in both strains. Doses of the drugs that did not disrupt responding in these experiments were tested in cocaine self-administration in experiment 3. Cocaine self-administration (0.25-1.0 mg/kg) was increased by eticlopride (0.03 mg/kg) in Lewis rats but had no effect in Fischer 344 rats, whereas SCH 23390 (0.01 mg/kg) led to greater increased cocaine self-administration in Fischer 344 versus Lewis rats. The dopamine agonists had differential effects on cocaine self-administration in the strains. Cocaine self-administration was decreased in Lewis rats and increased in Fischer 344 rats by SKF 38393 (1 mg/kg). These data show that manipulating D1- and D2-like receptor availability has strain-selective effects on the reinforcing, but not discriminative stimulus, effects of cocaine that are predicted by inherent differences in nucleus accumbens receptor populations. | lld:pubmed |
| pubmed-article:11602661 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11602661 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11602661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11602661 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11602661 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:11602661 | pubmed:author | pubmed-author:KostenT ATA | lld:pubmed |
| pubmed-article:11602661 | pubmed:author | pubmed-author:HaileC NCN | lld:pubmed |
| pubmed-article:11602661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11602661 | pubmed:volume | 299 | lld:pubmed |
| pubmed-article:11602661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11602661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11602661 | pubmed:pagination | 509-18 | lld:pubmed |
| pubmed-article:11602661 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:meshHeading | pubmed-meshheading:11602661... | lld:pubmed |
| pubmed-article:11602661 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11602661 | pubmed:articleTitle | Differential effects of D1- and D2-like compounds on cocaine self-administration in Lewis and Fischer 344 inbred rats. | lld:pubmed |
| pubmed-article:11602661 | pubmed:affiliation | Department of Psychiatry, Yale University School of Medicine, Hew Haven, Connecticut, USA. | lld:pubmed |
| pubmed-article:11602661 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11602661 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11602661 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11602661 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11602661 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11602661 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11602661 | lld:pubmed |
