| pubmed-article:11602253 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11602253 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:11602253 | lifeskim:mentions | umls-concept:C1458146 | lld:lifeskim |
| pubmed-article:11602253 | lifeskim:mentions | umls-concept:C0002812 | lld:lifeskim |
| pubmed-article:11602253 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:11602253 | lifeskim:mentions | umls-concept:C0032405 | lld:lifeskim |
| pubmed-article:11602253 | lifeskim:mentions | umls-concept:C1538577 | lld:lifeskim |
| pubmed-article:11602253 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:11602253 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11602253 | pubmed:dateCreated | 2001-10-16 | lld:pubmed |
| pubmed-article:11602253 | pubmed:abstractText | The molecular interactions of poly(ADP-ribose) polymerase I (PARP I) and topoisomerase I (Topo I) have been determined by the analysis of physical binding of the two proteins and some of their polypeptide components and by the effect of PARP I on the enzymatic catalysis of Topo I. Direct association of Topo I and PARP I as well as the binding of two Topo I polypeptides to PARP I are demonstrated. The effect of PARP I on the 'global' Topo I reaction (scission and religation), and the activation of Topo I by the 36 kDa polypeptide of PARP I and catalytic modifications by poly(ADP-ribosyl)ation are also shown. The covalent binding of Topo I to circular DNA is activated by PARP I similar to the degree of activation of the 'global' Topo I reaction, whereas the religation of DNA is unaffected by PARP I. The geometry of PARP I-Topo I interaction compared to automodified PARP I was reconstructed from direct binding assays between glutathione S-transferase fusion polypeptides of Topo I and PARP I demonstrating highly selective binding, which was correlated with amino acid sequences and with the 'C clamp' model derived from X-ray crystallography. | lld:pubmed |
| pubmed-article:11602253 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11602253 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602253 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11602253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602253 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602253 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11602253 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11602253 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:KunEE | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:BauerP IPI | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:HakamAA | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:ChewH CHC | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:KirstenEE | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:HwangJ IJI | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:CaseR ARA | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:KenesiEE | lld:pubmed |
| pubmed-article:11602253 | pubmed:author | pubmed-author:KenesseyII | lld:pubmed |
| pubmed-article:11602253 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11602253 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:11602253 | pubmed:volume | 506 | lld:pubmed |
| pubmed-article:11602253 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11602253 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11602253 | pubmed:pagination | 239-42 | lld:pubmed |
| pubmed-article:11602253 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11602253 | pubmed:meshHeading | pubmed-meshheading:11602253... | lld:pubmed |
| pubmed-article:11602253 | pubmed:meshHeading | pubmed-meshheading:11602253... | lld:pubmed |
| pubmed-article:11602253 | pubmed:meshHeading | pubmed-meshheading:11602253... | lld:pubmed |
| pubmed-article:11602253 | pubmed:meshHeading | pubmed-meshheading:11602253... | lld:pubmed |
| pubmed-article:11602253 | pubmed:meshHeading | pubmed-meshheading:11602253... | lld:pubmed |
| pubmed-article:11602253 | pubmed:meshHeading | pubmed-meshheading:11602253... | lld:pubmed |
| pubmed-article:11602253 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11602253 | pubmed:articleTitle | Molecular interactions between poly(ADP-ribose) polymerase (PARP I) and topoisomerase I (Topo I): identification of topology of binding. | lld:pubmed |
| pubmed-article:11602253 | pubmed:affiliation | Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary. | lld:pubmed |
| pubmed-article:11602253 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11602253 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11602253 | lld:pubmed |
