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pubmed-article:11602018pubmed:abstractTextAlthough a randomized trial represents the most rigorous method of evaluating a medical intervention, some interventions would be extremely difficult to evaluate using this study design. One alternative, an observational cohort study, can give biased results if it is not possible to adjust for all relevant risk factors.lld:pubmed
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pubmed-article:11602018pubmed:articleTitleThe paired availability design for historical controls.lld:pubmed
pubmed-article:11602018pubmed:affiliationDivision of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. sb16i@nih.govlld:pubmed
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