| pubmed-article:11598150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C1550315 | lld:lifeskim |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C0282553 | lld:lifeskim |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C1819426 | lld:lifeskim |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11598150 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11598150 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11598150 | pubmed:dateCreated | 2001-10-12 | lld:pubmed |
| pubmed-article:11598150 | pubmed:abstractText | Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and in synovial tissues from patients with rheumatoid arthritis (RA). To determine the participation of IL-18 in the inflammation observed in RA, we investigated the effect of IL-18 on RA synovial fibroblast chemokine production. Using FACS analysis, we showed that IL-18 induced a doubling in the production of intracellular IL-8 by RA synovial fibroblasts, and this result was confirmed by Western blot. At the extracellular level, IL-18 up-regulated the secretion of IL-8 in a dose- and time-dependent manner. IL-18 also up-regulated the other CXC chemokines, epithelial-neutrophil activating protein (ENA-78) and growth-regulated oncogene (groalpha), in a dose dependent manner, but failed to induce the production of the CC chemokine, macrophage inflammatory protein (MIP)-1alpha. By immunofluorescence and Western blot, we demonstrated that IL-18 activates the translocation of the transcription factor nuclear factor kappa B (NFkappaB) into the nucleus of RA synovial fibroblasts. IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44% less IL-8 compared with cells pretreated with the control sense oligonucleotide. These results indicate a novel role for IL-18 in inducing RA synovial fibroblast expression of CXC chemokines through NFkappaB and place this cytokine in a strategic role in the local inflammation observed in RA. | lld:pubmed |
| pubmed-article:11598150 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11598150 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11598150 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11598150 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11598150 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11598150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11598150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11598150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11598150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11598150 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11598150 | pubmed:issn | 0023-6837 | lld:pubmed |
| pubmed-article:11598150 | pubmed:author | pubmed-author:KumarPP | lld:pubmed |
| pubmed-article:11598150 | pubmed:author | pubmed-author:KochA EAE | lld:pubmed |
| pubmed-article:11598150 | pubmed:author | pubmed-author:ParkC CCC | lld:pubmed |
| pubmed-article:11598150 | pubmed:author | pubmed-author:MorelJ CJC | lld:pubmed |
| pubmed-article:11598150 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11598150 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:11598150 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11598150 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11598150 | pubmed:pagination | 1371-83 | lld:pubmed |
| pubmed-article:11598150 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:meshHeading | pubmed-meshheading:11598150... | lld:pubmed |
| pubmed-article:11598150 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11598150 | pubmed:articleTitle | Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation. | lld:pubmed |
| pubmed-article:11598150 | pubmed:affiliation | Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA. | lld:pubmed |
| pubmed-article:11598150 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11598150 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11598150 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11598150 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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