| pubmed-article:11597376 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C1457887 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C1568868 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C0332237 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C0023981 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C1522168 | lld:lifeskim |
| pubmed-article:11597376 | lifeskim:mentions | umls-concept:C2926735 | lld:lifeskim |
| pubmed-article:11597376 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:11597376 | pubmed:dateCreated | 2001-10-12 | lld:pubmed |
| pubmed-article:11597376 | pubmed:abstractText | We have conducted a prospective controlled randomised clinical study testing for the efficacy of topical GM-CSF (molgramostim), as compared to the combined topical use of an antiseptic agent (povidone-iodine) and amphotericin B (AA) in patients with chemotherapy-induced mucositis World Health Organization (WHO) grades I-III. 31 patients (17 females, 14 males) developing oral mucositis following the administration of 5-fluorouracil (5-FU)-based chemotherapy were entered into the present trial. 15 patients were randomised to receive GM-CSF mouthwashes, whereas 16 patients were randomised into the control arm to receive AA. Reported history (P=0.6109) and grading of oral mucositis (2.1+/-0.7, respectively; P=0.9867) were balanced and equally distributed between the two groups. The mean size of lesions of oral mucositis was 1.5+/-0.6 cm (range: 0.7-2.5 cm) in the GM-CSF group and 1.2+/-0.5 cm (range: 0.5-2.5 cm) in the AA group (P=0.08), respectively. The mean number of oral mucositis lesions was 1.9+/-1.1 (range: 1-4) in the GM-CSF group and 2.1+/-1.2 (range: 1-4) in the AA group (P=0.63), respectively. None of the patients had previously received colony stimulating factors either topically or systemically. Treatment for oral mucositis was initiated on day 2.7+/-1.2 (range: day 1-8) after onset of symptoms in the GM-CSF group and on day 1.8+/-1.4 (range: day 1-3; P=0.11) in the AA group. The topical application of GM-CSF resulted in a significantly shorter duration and quicker resolution of oral mucositis, as compared to AA including both, pretreatment plus treatment periods (5.3+/-2.5 versus 8.1+/-1.5 days; P=0.0008) as well as the necessary duration of treatment needed until complete remission of lesions (2.8+/-0.7 versus 6.3+/-1.1 days; P<0.0001). A systemic effect of topical GM-CSF upon the number of peripheral blood leukocytes or granulocytes was excluded. We conclude that the topical application of GM-CSF by mouthwash significantly abbreviated the duration and relieved patients from symptoms of chemotherapy-induced mucositis and was superior to the topical application of AA. | lld:pubmed |
| pubmed-article:11597376 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11597376 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11597376 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11597376 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11597376 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11597376 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11597376 | pubmed:issn | 0959-8049 | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:ZielinskiC... | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:ScheithauerWW | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:WiltschkeCC | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:StegerG GGG | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:RadererMM | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:BrodowiczTT | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:HejnaMM | lld:pubmed |
| pubmed-article:11597376 | pubmed:author | pubmed-author:KöstlerW JWJ | lld:pubmed |
| pubmed-article:11597376 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11597376 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:11597376 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11597376 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11597376 | pubmed:pagination | 1994-2002 | lld:pubmed |
| pubmed-article:11597376 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:11597376 | pubmed:meshHeading | pubmed-meshheading:11597376... | lld:pubmed |
| pubmed-article:11597376 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11597376 | pubmed:articleTitle | Decrease of duration and symptoms in chemotherapy-induced oral mucositis by topical GM-CSF: results of a prospective randomised trial. | lld:pubmed |
| pubmed-article:11597376 | pubmed:affiliation | Department of Medicine I, Division of Oncology, University Hospital, 18-20 Waehringer Guertel, A-1090, Vienna, Austria. | lld:pubmed |
| pubmed-article:11597376 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11597376 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11597376 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11597376 | lld:pubmed |
