| pubmed-article:11593024 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C0017258 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C1156200 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C0002270 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C1516960 | lld:lifeskim |
| pubmed-article:11593024 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:11593024 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11593024 | pubmed:dateCreated | 2001-10-10 | lld:pubmed |
| pubmed-article:11593024 | pubmed:abstractText | We have analyzed the pattern of core histone acetylation across 250 kb of the telomeric region of the short arm of human chromosome 16. This gene-dense region, which includes the alpha-globin genes and their regulatory elements embedded within widely expressed genes, shows marked differences in histone acetylation between erythroid and non-erythroid cells. In non-erythroid cells, there was a uniform 2- to 3-fold enrichment of acetylated histones, compared with heterochromatin, across the entire region. In erythroid cells, an approximately 100-kb segment of chromatin encompassing the alpha genes and their remote major regulatory element was highly enriched in histone H4 acetylated at Lys-5. Other lysines in the N-terminal tail of histone H4 showed intermediate and variable levels of enrichment. Similar broad segments of erythroid-specific histone acetylation were found in the corresponding syntenic regions containing the mouse and chicken alpha-globin gene clusters. The borders of these regions of acetylation are located in similar positions in all three species, and a sharply defined 3' boundary coincides with the previously identified breakpoint in conserved synteny between these species. We have therefore demonstrated that an erythroid-specific domain of acetylation has been conserved across several species, encompassing not only the alpha-globin genes but also a neighboring widely expressed gene. These results contrast with those at other clusters and demonstrate that not all genes are organized into discrete regulatory domains. | lld:pubmed |
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| pubmed-article:11593024 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11593024 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11593024 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11593024 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11593024 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11593024 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11593024 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11593024 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11593024 | pubmed:author | pubmed-author:WoodW GWG | lld:pubmed |
| pubmed-article:11593024 | pubmed:author | pubmed-author:JohnsonC ACA | lld:pubmed |
| pubmed-article:11593024 | pubmed:author | pubmed-author:TurnerB MBM | lld:pubmed |
| pubmed-article:11593024 | pubmed:author | pubmed-author:HiggsD RDR | lld:pubmed |
| pubmed-article:11593024 | pubmed:author | pubmed-author:AnguitaEE | lld:pubmed |
| pubmed-article:11593024 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11593024 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:11593024 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11593024 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11593024 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11593024 | pubmed:pagination | 12114-9 | lld:pubmed |
| pubmed-article:11593024 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
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| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
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| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:meshHeading | pubmed-meshheading:11593024... | lld:pubmed |
| pubmed-article:11593024 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11593024 | pubmed:articleTitle | Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster. | lld:pubmed |
