| pubmed-article:11591793 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11591793 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11591793 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11591793 | pubmed:dateCreated | 2001-10-9 | lld:pubmed |
| pubmed-article:11591793 | pubmed:abstractText | Macrophage-inflammatory protein 2 (MIP-2) is a major CXC chemokine involved in the migration of polymorphonuclear neutrophils (PMNs) to sites of inflammation. Although cell culture experiments have identified different cell types that can produce MIP-2, the cellular sources in vivo are not clearly defined. By using immunohistochemical staining and analysis of chemokine mRNA expression, the present study aimed to localize cells producing MIP-2 in tissues of normal mice and mice challenged with Yersinia enterocolitica. The results showed a constitutive expression of MIP-2 mRNA in bone marrow (BM) of normal mice, but not in other organs such as spleen, lung, or liver. MIP-2 protein was found in all organs tested but it was exclusively associated with PMNs that stained positive with the cell surface marker Gr-1. Bacterial infection caused a 5-fold increase in the number of MIP-2-positive PMNs recruited to spleens concomitant with a strong increase of splenic MIP-2 mRNA. This correlated well with a 3-fold loss of MIP-2-producing cells in BM. Because MIP-2 mRNA expression in PMNs was increased after stimulation with TNF, the results indicate that newly recruited PMNs can supplement their MIP-2 content through TNF-stimulated transcription. Together, the data imply a constitutive production of MIP-2 by a subset of PMNs in BM and argue for the possibility of a rapid mobilization of MIP-2 through its storage in circulating PMNs. | lld:pubmed |
| pubmed-article:11591793 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11591793 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11591793 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11591793 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11591793 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11591793 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11591793 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11591793 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11591793 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11591793 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11591793 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11591793 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11591793 | pubmed:author | pubmed-author:RöllinghoffMM | lld:pubmed |
| pubmed-article:11591793 | pubmed:author | pubmed-author:BaumannTT | lld:pubmed |
| pubmed-article:11591793 | pubmed:author | pubmed-author:BeuscherH UHU | lld:pubmed |
| pubmed-article:11591793 | pubmed:author | pubmed-author:LukacsN WNW | lld:pubmed |
| pubmed-article:11591793 | pubmed:author | pubmed-author:MatzerS PSP | lld:pubmed |
| pubmed-article:11591793 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11591793 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11591793 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11591793 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11591793 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11591793 | pubmed:pagination | 4635-43 | lld:pubmed |
| pubmed-article:11591793 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11591793 | pubmed:meshHeading | pubmed-meshheading:11591793... | lld:pubmed |
| pubmed-article:11591793 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11591793 | pubmed:articleTitle | Constitutive expression of macrophage-inflammatory protein 2 (MIP-2) mRNA in bone marrow gives rise to peripheral neutrophils with preformed MIP-2 protein. | lld:pubmed |
| pubmed-article:11591793 | pubmed:affiliation | Institute for Clinical Microbiology, Immunology, and Hygiene, University of Erlangen, Erlangen, Germany. | lld:pubmed |
| pubmed-article:11591793 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11591793 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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