Linked Life Data

11591771

Source:http://linkedlifedata.com/resource/pubmed/id/11591771

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pubmed-article:11591771pubmed:abstractTextMurine models of lymphocytic choriomeningitis virus infection suggest that the memory CD8(+) T cell repertoire is reflective of the CD8(+) T cell repertoire generated during acute infection. Less is known regarding the evolution of CD8(+) T cell repertoires during human viral infections. We therefore examined epitope-specific CD8(+) T cell responses in a large cohort of individuals with acute through latent Epstein-Barr virus infection. Using 16 of 20 published EBV epitopes restricted by HLA-A2, HLA-A3 or HLA-B7, we showed that lytic cycle-specific CD8(+) T cell responses predominated during acute EBV infection. However, whereas HLA-A2(+)-restricted BMLF-1-specific CD8(+) T cell responses were maintained through latency, HLA-A2(+)- and HLA-B7(+)-restricted BZLF-1, as well as HLA-A3(+)-restricted BRLF-1 CD8(+) T cell responses, were generated but not readily maintained. Analyses of CD8(+) T cell responses to EBV latent cycle Ags showed delayed detection and lower frequencies of latent epitope-specific CD8(+) T cell responses during acute EBV infection, with maintenance of these responses 1 yr post-EBV infection. Early BMLF-1 and EBNA-3A epitope-specific CD8(+) T cell frequencies did not correlate with their frequencies at 1 yr postinfection. Interestingly, populations of EBV-specific CD8(+) T cells were stable during 20 mo in our long term EBV-seropositive populations, suggesting homeostasis between virus and the host immune system. This study demonstrates that CD8(+) T cell repertoires generated during persistent viral infections are not simply reflective of the initial pool of CD8(+) T cells and provides evidence that the generation of CD8(+) T cell responses to a persistent infection is a dynamic process.lld:pubmed
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pubmed-article:11591771pubmed:authorpubmed-author:SullivanJ LJLlld:pubmed
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pubmed-article:11591771pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11591771pubmed:articleTitleDifferential evolution and stability of epitope-specific CD8(+) T cell responses in EBV infection.lld:pubmed
pubmed-article:11591771pubmed:affiliationDepartment of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.lld:pubmed
pubmed-article:11591771pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11591771pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:11591771pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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