| pubmed-article:11589692 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11589692 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11589692 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:11589692 | lifeskim:mentions | umls-concept:C0599895 | lld:lifeskim |
| pubmed-article:11589692 | lifeskim:mentions | umls-concept:C1512571 | lld:lifeskim |
| pubmed-article:11589692 | lifeskim:mentions | umls-concept:C0598002 | lld:lifeskim |
| pubmed-article:11589692 | lifeskim:mentions | umls-concept:C0205423 | lld:lifeskim |
| pubmed-article:11589692 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:11589692 | pubmed:dateCreated | 2001-10-8 | lld:pubmed |
| pubmed-article:11589692 | pubmed:abstractText | Gram-negative bacteria are enveloped by a system of two membranes, and they use specialized multicomponent, energy-driven pumps to transport molecules directly across this double-layered partition from the cell interior to the extra-cellular environment. One component of these pumps is embedded in the outer-membrane, and the paradigm for its structure and function is the TolC protein from Escherichia coli. A common component of a wide variety of efflux pumps, TolC and its homologues are involved in the export of chemically diverse molecules ranging from large protein toxins, such as alpha-hemolysin, to small toxic compounds, such as antibiotics. TolC family members thus play important roles in conferring pathogenic bacteria with both virulence and multidrug resistance. These pumps assemble reversibly in a transient process that brings together TolC or its homologue, an inner-membrane-associated periplasmic component, an integral inner-membrane translocase and the substrate itself. TolC can associate in this fashion with a variety of different partners to participate in the transport of diverse substrates. We review here the structure and function of TolC and the other components of the efflux/transport pump. | lld:pubmed |
| pubmed-article:11589692 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11589692 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11589692 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11589692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11589692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11589692 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11589692 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11589692 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:11589692 | pubmed:author | pubmed-author:ShaRR | lld:pubmed |
| pubmed-article:11589692 | pubmed:author | pubmed-author:LuisiBB | lld:pubmed |
| pubmed-article:11589692 | pubmed:author | pubmed-author:FanuttiCC | lld:pubmed |
| pubmed-article:11589692 | pubmed:author | pubmed-author:SharffAA | lld:pubmed |
| pubmed-article:11589692 | pubmed:author | pubmed-author:CalladineCC | lld:pubmed |
| pubmed-article:11589692 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11589692 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:11589692 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11589692 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11589692 | pubmed:pagination | 5011-26 | lld:pubmed |
| pubmed-article:11589692 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
| pubmed-article:11589692 | pubmed:meshHeading | pubmed-meshheading:11589692... | lld:pubmed |
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| pubmed-article:11589692 | pubmed:meshHeading | pubmed-meshheading:11589692... | lld:pubmed |
| pubmed-article:11589692 | pubmed:meshHeading | pubmed-meshheading:11589692... | lld:pubmed |
| pubmed-article:11589692 | pubmed:meshHeading | pubmed-meshheading:11589692... | lld:pubmed |
| pubmed-article:11589692 | pubmed:meshHeading | pubmed-meshheading:11589692... | lld:pubmed |
| pubmed-article:11589692 | pubmed:meshHeading | pubmed-meshheading:11589692... | lld:pubmed |
| pubmed-article:11589692 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11589692 | pubmed:articleTitle | The role of the TolC family in protein transport and multidrug efflux. From stereochemical certainty to mechanistic hypothesis. | lld:pubmed |
| pubmed-article:11589692 | pubmed:affiliation | Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. | lld:pubmed |
| pubmed-article:11589692 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11589692 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:11589692 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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