| pubmed-article:11589508 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11589508 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11589508 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11589508 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:11589508 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:11589508 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:11589508 | lifeskim:mentions | umls-concept:C0013125 | lld:lifeskim |
| pubmed-article:11589508 | lifeskim:mentions | umls-concept:C0383873 | lld:lifeskim |
| pubmed-article:11589508 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:11589508 | pubmed:dateCreated | 2001-10-8 | lld:pubmed |
| pubmed-article:11589508 | pubmed:abstractText | LY303870 (LY) is a non-peptide neurokinin-1 receptor antagonist that has effects on the brain after peripheral administration. We determined whether LY given by intravenous (iv) injection can cross the blood-brain barrier (BBB). Multiple-time regression analysis showed the unidirectional influx rate (Ki) from blood to brain for LY labeled with tritium to be 6.41+/-0.85 microl/g-min and influx was inhibited by unlabeled LY. HPLC and mass spectrometry showed LY was stable in blood and brain. LY reached a brain/serum ratio of 190+/-12 microl/g with about 0.07% of the injected dose entering each gram of brain. These results show that LY is transported across the BBB from serum into brain by a saturable system. | lld:pubmed |
| pubmed-article:11589508 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11589508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11589508 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11589508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11589508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11589508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11589508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11589508 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11589508 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11589508 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:11589508 | pubmed:author | pubmed-author:BanksW AWA | lld:pubmed |
| pubmed-article:11589508 | pubmed:author | pubmed-author:IyengarSS | lld:pubmed |
| pubmed-article:11589508 | pubmed:author | pubmed-author:McMillianC... | lld:pubmed |
| pubmed-article:11589508 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11589508 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:11589508 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:11589508 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11589508 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11589508 | pubmed:pagination | 1683-9 | lld:pubmed |
| pubmed-article:11589508 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:meshHeading | pubmed-meshheading:11589508... | lld:pubmed |
| pubmed-article:11589508 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11589508 | pubmed:articleTitle | Saturable transport of the neurokinin-1 non-peptide antagonist LY303870 across the rat blood-brain barrier after intravenous administration. | lld:pubmed |
| pubmed-article:11589508 | pubmed:affiliation | GRECC, Veterans Affairs Medical Center-St. Louis, Department of Internal Medicine, Saint Louis University School of Medicine, MO 63106, USA. bankswa@slu.edu | lld:pubmed |
| pubmed-article:11589508 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11589508 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
