| pubmed-article:11578523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11578523 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:11578523 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:11578523 | lifeskim:mentions | umls-concept:C0018061 | lld:lifeskim |
| pubmed-article:11578523 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:11578523 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11578523 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:11578523 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11578523 | pubmed:dateCreated | 2001-10-1 | lld:pubmed |
| pubmed-article:11578523 | pubmed:abstractText | Double-label immunohistochemistry was employed to establish whether immunoreactivity for the beta subtype of the oestrogen receptor (ER beta-IR) is present in gonadotropin releasing hormone (GnRH)-containing cells. In the immortalized GnRH cell line, GT1-7, almost all nuclei were immunoreactive for ER beta. In the preoptic area of ovariectomized rats, more than one-half of the GnRH neurones (52.0-63.5%) contained ER beta-IR within the nucleus; a smaller proportion of these neurones (5-10%) displayed a particularly intense nuclear signal for ER beta. The presence of ER beta-IR in the nuclei of GT1-7 cells and GnRH neurones is consistent with recent reports of ER beta mRNA in these cells. Oestrogen treatment reduced the percentage of GnRH neurones with detectable ER beta-IR. The range of signal intensity for ER beta and the incidence of the ER beta signal in GnRH neurones were comparable following double-label immunohistochemistry involving either bright field or fluorescent techniques. These findings raise the possibility that ER beta receptors mediate direct effects of oestrogen on GnRH neurones. | lld:pubmed |
| pubmed-article:11578523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11578523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11578523 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11578523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11578523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11578523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11578523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11578523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11578523 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11578523 | pubmed:issn | 0953-8194 | lld:pubmed |
| pubmed-article:11578523 | pubmed:author | pubmed-author:GistD HDH | lld:pubmed |
| pubmed-article:11578523 | pubmed:author | pubmed-author:ButlerJ AJA | lld:pubmed |
| pubmed-article:11578523 | pubmed:author | pubmed-author:KallóII | lld:pubmed |
| pubmed-article:11578523 | pubmed:author | pubmed-author:Barkovics-Kal... | lld:pubmed |
| pubmed-article:11578523 | pubmed:author | pubmed-author:GoubillonM... | lld:pubmed |
| pubmed-article:11578523 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11578523 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:11578523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11578523 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11578523 | pubmed:pagination | 741-8 | lld:pubmed |
| pubmed-article:11578523 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:meshHeading | pubmed-meshheading:11578523... | lld:pubmed |
| pubmed-article:11578523 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11578523 | pubmed:articleTitle | Oestrogen receptor beta-immunoreactivity in gonadotropin releasing hormone-expressing neurones: regulation by oestrogen. | lld:pubmed |
| pubmed-article:11578523 | pubmed:affiliation | Centre for Neuroscience Research, King's College London, London, UK. imre.kallo@kcl.ac.uk | lld:pubmed |
| pubmed-article:11578523 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11578523 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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