| pubmed-article:11568019 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C2323499 | lld:lifeskim |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C1418188 | lld:lifeskim |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C1424223 | lld:lifeskim |
| pubmed-article:11568019 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:11568019 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11568019 | pubmed:dateCreated | 2001-9-24 | lld:pubmed |
| pubmed-article:11568019 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11568019 | pubmed:abstractText | Using differential display polymerase chain reaction, a gene was identified in CD34(+)-enriched populations that had with low or absent expression in CD34(-) populations. The full coding sequence of this transcript was obtained, and the predicted protein has a high degree of homology to oxysterol-binding protein. This gene has been designated OSBP-related protein 3 (ORP-3). Expression of ORP-3 was found to be 3- to 4-fold higher in CD34(+) cells than in CD34(-) cells. Additionally, expression of this gene was 2-fold higher in the more primitive subfraction of hematopoietic cells defined by the CD34(+)38(-) phenotype and was down-regulated with the proliferation and differentiation of CD34(+) cells. The ORP-3 predicted protein contains an oxysterol-binding domain. Well-characterized proteins expressing this domain bind oxysterols in a dose-dependent fashion. Biologic activities of oxysterols include inhibition of cholesterol biosynthesis and cell proliferation in a variety of cell types, among them hematopoietic cells. Characterization and differential expression of ORP-3 implicates a possible role in the mediation of oxysterol effects on hematopoiesis. | lld:pubmed |
| pubmed-article:11568019 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11568019 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11568019 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11568019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11568019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11568019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11568019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11568019 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11568019 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11568019 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11568019 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:11568019 | pubmed:author | pubmed-author:KirklandM AMA | lld:pubmed |
| pubmed-article:11568019 | pubmed:author | pubmed-author:CollierG RGR | lld:pubmed |
| pubmed-article:11568019 | pubmed:author | pubmed-author:CollierF MFM | lld:pubmed |
| pubmed-article:11568019 | pubmed:author | pubmed-author:McMillanJ SJS | lld:pubmed |
| pubmed-article:11568019 | pubmed:author | pubmed-author:WaughC MCM | lld:pubmed |
| pubmed-article:11568019 | pubmed:author | pubmed-author:McLeodJ LJL | lld:pubmed |
| pubmed-article:11568019 | pubmed:author | pubmed-author:Gregorio-King... | lld:pubmed |
| pubmed-article:11568019 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11568019 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11568019 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11568019 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11568019 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11568019 | pubmed:pagination | 2279-81 | lld:pubmed |
| pubmed-article:11568019 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:meshHeading | pubmed-meshheading:11568019... | lld:pubmed |
| pubmed-article:11568019 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11568019 | pubmed:articleTitle | ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells. | lld:pubmed |
| pubmed-article:11568019 | pubmed:affiliation | Stem Cell Laboratory, Douglas Hocking Research Institute, Barwon Health, The Geelong Hospital, Geelong Victoria, Australia. ccgk@deakin.edu.au | lld:pubmed |
| pubmed-article:11568019 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11568019 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:26031 | entrezgene:pubmed | pubmed-article:11568019 | lld:entrezgene |
