| pubmed-article:11566613 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11566613 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11566613 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:11566613 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11566613 | lifeskim:mentions | umls-concept:C1514713 | lld:lifeskim |
| pubmed-article:11566613 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11566613 | pubmed:dateCreated | 2001-9-21 | lld:pubmed |
| pubmed-article:11566613 | pubmed:abstractText | We discuss the biology of Ras signal transduction and the epidemiology of ras mutations in association with disease as a background for the development of a Raf kinase inhibitor, BAY 43-9006. Knowledge of Ras effector pathways has permitted genetic validation of numerous targets involved in the Ras signaling cascade. A key Ras effector pathway involves the kinase cascade RAF/MEK/ERK (MEK: MAP/ERK kinase; ERK: extracellular signal related kinase). Indeed, we present studies of cell lines stably expressing mutant MEK constructs, which point to Raf kinase as a target for therapeutics with selective anti-tumor activity. Finally, a small molecule drug discovery program based on inhibition of Raf kinase activity is outlined and the initial pre-clinical development process of the Raf kinase inhibitor BAY 43-9006 is discussed. | lld:pubmed |
| pubmed-article:11566613 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11566613 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11566613 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11566613 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11566613 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11566613 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11566613 | pubmed:issn | 1351-0088 | lld:pubmed |
| pubmed-article:11566613 | pubmed:author | pubmed-author:BollagGG | lld:pubmed |
| pubmed-article:11566613 | pubmed:author | pubmed-author:WilhelmSS | lld:pubmed |
| pubmed-article:11566613 | pubmed:author | pubmed-author:LyonsJ FJF | lld:pubmed |
| pubmed-article:11566613 | pubmed:author | pubmed-author:HibnerBB | lld:pubmed |
| pubmed-article:11566613 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11566613 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:11566613 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11566613 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11566613 | pubmed:pagination | 219-25 | lld:pubmed |
| pubmed-article:11566613 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:11566613 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11566613 | pubmed:articleTitle | Discovery of a novel Raf kinase inhibitor. | lld:pubmed |
| pubmed-article:11566613 | pubmed:affiliation | Onyx Pharmaceuticals, 3031 Research Drive, Richmond, California 94806, USA. jlyons1@ireland.com | lld:pubmed |
| pubmed-article:11566613 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11566613 | pubmed:publicationType | Review | lld:pubmed |
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