| pubmed-article:11560926 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C2700455 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C0338451 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C0242422 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C0008659 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C0002345 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C1947976 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C1947974 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:11560926 | lifeskim:mentions | umls-concept:C1720655 | lld:lifeskim |
| pubmed-article:11560926 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:11560926 | pubmed:dateCreated | 2001-11-12 | lld:pubmed |
| pubmed-article:11560926 | pubmed:abstractText | Mutations in the human tau gene cause frontotemporal dementia and Parkinsonism associated with chromosome 17 (FTDP-17). One of the major disease mechanisms in FTDP-17 is the increased inclusion of tau exon 10 during pre-mRNA splicing. Here we show that modified oligonucleotides directed against the tau exon 10 splice junctions suppress inclusion of tau exon 10. The effect is mediated by the formation of a stable pre-mRNA-oligonucleotide hybrid, which blocks access of the splicing machinery to the pre-mRNA. Correction of tau splicing occurs in a tau minigene system and in endogenous tau RNA in neuronal pheochromocytoma cells and is specific to exon 10 of the tau gene. Antisense oligonucleotide-mediated exclusion of exon 10 has a physiological effect by increasing the ratio of protein lacking the microtubule-binding domain encoded by exon 10. As a consequence, the microtubule cytoskeleton becomes destabilized and cell morphology is altered. Our results demonstrate that alternative splicing defects of tau as found in FTDP-17 patients can be corrected by application of antisense oligonucleotides. These findings provide a tool to study specific tau isoforms in vivo and might lead to a novel therapeutic strategy for FTDP-17. | lld:pubmed |
| pubmed-article:11560926 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11560926 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11560926 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11560926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11560926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11560926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11560926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11560926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11560926 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11560926 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11560926 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11560926 | pubmed:author | pubmed-author:MisteliTT | lld:pubmed |
| pubmed-article:11560926 | pubmed:author | pubmed-author:MabonS ASA | lld:pubmed |
| pubmed-article:11560926 | pubmed:author | pubmed-author:KalbfussBB | lld:pubmed |
| pubmed-article:11560926 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11560926 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:11560926 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11560926 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11560926 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11560926 | pubmed:pagination | 42986-93 | lld:pubmed |
| pubmed-article:11560926 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:meshHeading | pubmed-meshheading:11560926... | lld:pubmed |
| pubmed-article:11560926 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11560926 | pubmed:articleTitle | Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17. | lld:pubmed |
| pubmed-article:11560926 | pubmed:affiliation | National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:11560926 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11560926 | lld:pubmed |
