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pubmed-article:11558431pubmed:abstractTextThe clinico-pharmacological and pharmacokinetic investigation of mexidole administered in patients with organic CNS damage showed for the first time that there is a correlation between intensity of the drug--glucurone conjugation and the parameters of psychopathological symptom expression and the individual patient state estimation before treatment and upon a single administration or a course of mexidole therapy. This correlation allows the clinico-pharmacological effects and the therapeutic efficacy of mexidole to be predicted based on the drug metabolism index.lld:pubmed
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pubmed-article:11558431pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11558431pubmed:articleTitle[Relation between mexidol glucuronide conjugation and characteristics of its therapeutic effect in patients with organic lesions in the central nervous system].lld:pubmed
pubmed-article:11558431pubmed:affiliationLaboratory of Pharmacokinetics, Laboratory of Clinical Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.lld:pubmed
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