| pubmed-article:11555654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C0065088 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C1622946 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11555654 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:11555654 | pubmed:issue | 46 | lld:pubmed |
| pubmed-article:11555654 | pubmed:dateCreated | 2001-11-12 | lld:pubmed |
| pubmed-article:11555654 | pubmed:abstractText | Lithium affects several enzymatic activities, however, the molecular mechanisms of lithium actions are not fully understood. We previously showed that LiCl interacts synergistically with all-trans-retinoic acid to promote terminal differentiation of WEHI-3B D(+) cells, a phenomenon accompanied by the recovery of the retinoid-induced loss of retinoic acid receptor alpha protein pools. Here, we demonstrate the effects of LiCl on proteasome-dependent degradation of retinoic acid receptor alpha proteins. LiCl alone, or in combination with all-trans-retinoic acid, increased cellular levels of ubiquitinated retinoic acid receptor alpha and markedly reduced chymotryptic-like activity of WEHI-3B D(+) 20 S and 26 S proteasome enzymes. Neither KCl nor all-trans-retinoic acid affected enzyme activity, whereas NaCl produced a modest reduction at relatively high concentrations. In addition, LiCl inhibited 20 S proteasome chymotryptic-like activity from rabbits but had no effect on tryptic-like activity of the 26 S proteasome. This effect has significant consequences in stabilizing the retinoic acid receptor alpha protein levels that are necessary to promote continued differentiation of leukemia cells in response to all-trans-retinoic acid. In support of this concept, combination of proteasome inhibitors beta-clastolactacystin or benzyloxycarbonyl-Leu-Leu-Phe with all-trans-retinoic acid increased differentiation of WEHI-3B D(+) cells in a manner that was analogous to the combination of LiCl and all-trans-retinoic acid. | lld:pubmed |
| pubmed-article:11555654 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11555654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11555654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11555654 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11555654 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11555654 | pubmed:author | pubmed-author:SartorelliA... | lld:pubmed |
| pubmed-article:11555654 | pubmed:author | pubmed-author:RiceA MAM | lld:pubmed |
| pubmed-article:11555654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11555654 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:11555654 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11555654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11555654 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11555654 | pubmed:pagination | 42722-7 | lld:pubmed |
| pubmed-article:11555654 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11555654 | pubmed:meshHeading | pubmed-meshheading:11555654... | lld:pubmed |
| pubmed-article:11555654 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11555654 | pubmed:articleTitle | Inhibition of 20 S and 26 S proteasome activity by lithium chloride: impact on the differentiation of leukemia cells by all-trans retinoic acid. | lld:pubmed |
| pubmed-article:11555654 | pubmed:affiliation | Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA. | lld:pubmed |
| pubmed-article:11555654 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11555654 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11555654 | lld:pubmed |
