| pubmed-article:11544302 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0385242 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:11544302 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11544302 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11544302 | pubmed:dateCreated | 2001-9-6 | lld:pubmed |
| pubmed-article:11544302 | pubmed:abstractText | The NF-kappaB family of transcription factors functions broadly in the host control of immunoregulatory gene expression, inflammation, and apoptosis. Using Jurkat T cells engineered to inducibly express a transdominant repressor of IkappaBalpha, we examined the role of NF-kappaB in the regulation of cytokine and apoptotic gene expression. In this T cell model, as well as in primary T lymphocytes, expression of TNF-related apoptosis-inducing ligand (TRAIL) apoptotic signaling protein was dramatically down-regulated by inhibition of NF-kappaB binding activity. TRAIL acts through membrane death receptors to induce apoptosis of activated T lymphocytes and can be up-regulated by a variety of physiological and pharmacological inducers. However, regulation of TRAIL gene expression has not been defined. Treatment with TCR mimetics (PMA/ionomycin, PHA, and anti-CD3/CD28 Abs) resulted in a rapid increase in the expression of TRAIL mRNA and cell surface TRAIL protein. Induction of the transdominant repressor of IkappaBalpha dramatically down-regulated surface expression of TRAIL, indicating an essential role for NF-kappaB in the regulation of TRAIL. The induced expression of TRAIL was linked to a c-Rel binding site in the proximal TRAIL promoter at position -256 to -265; mutation of this site or an adjacent kappaB site resulted in a complete loss of the inducibility of the TRAIL promoter. The regulation of TRAIL expression by NF-kappaB may represent a general mechanism that contributes to the control of TRAIL-mediated apoptosis in T lymphocytes. | lld:pubmed |
| pubmed-article:11544302 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11544302 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11544302 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11544302 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11544302 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11544302 | pubmed:author | pubmed-author:SharmaSS | lld:pubmed |
| pubmed-article:11544302 | pubmed:author | pubmed-author:HiscottJJ | lld:pubmed |
| pubmed-article:11544302 | pubmed:author | pubmed-author:KwonHH | lld:pubmed |
| pubmed-article:11544302 | pubmed:author | pubmed-author:GrandvauxNN | lld:pubmed |
| pubmed-article:11544302 | pubmed:author | pubmed-author:BaetuT MTM | lld:pubmed |
| pubmed-article:11544302 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11544302 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11544302 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11544302 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11544302 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11544302 | pubmed:pagination | 3164-73 | lld:pubmed |
| pubmed-article:11544302 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11544302 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11544302 | pubmed:articleTitle | Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression. | lld:pubmed |
| pubmed-article:11544302 | pubmed:affiliation | Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada. | lld:pubmed |
| pubmed-article:11544302 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11544302 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11544302 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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