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pubmed-article:11540050pubmed:dateCreated1997-10-18lld:pubmed
pubmed-article:11540050pubmed:abstractTextThe effects of amine structure on the montmorillonite-catalyzed oligomerization of the 5'-phosphoramidates of adenosine are investigated. 4-Aminopyridine derivatives yielded oligoadenylates as long as dodecamers with a regioselectivity for 3',5'-phosphodiester bond formation averaging 88%. Linear and cyclic oligomers are obtained and no A5'ppA-containing products are detected. Oligomers as long as the hexanucleotide are obtained using 2-aminobenzimidazole as the activating group. A predominance of pA2'pA is detected in the dimer fraction along with cyclic 3',5'-trimer; no A5'ppA-containing oligomers were detected. Little or no oligomer formation was observed when morpholine, piperidine, pyrazole, 1,2,4-triazole, and 2-pyridone are used as phosphate-activating groups. The effects of the structure of the phosphate activating group on the oligomer structure and chain lengths are discussed.lld:pubmed
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pubmed-article:11540050pubmed:authorpubmed-author:FerrisJ PJPlld:pubmed
pubmed-article:11540050pubmed:authorpubmed-author:PrabaharK JKJlld:pubmed
pubmed-article:11540050pubmed:authorpubmed-author:ColeT DTDlld:pubmed
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pubmed-article:11540050pubmed:pagination10914-20lld:pubmed
pubmed-article:11540050pubmed:dateRevised2007-8-1lld:pubmed
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pubmed-article:11540050pubmed:articleTitleEffect of phosphate activating group on oligonucleotide formation on montmorillonite: the regioselective formation of 3',5'-linked oligoadenylates.lld:pubmed
pubmed-article:11540050pubmed:affiliationDepartment of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180-3590, USA.lld:pubmed
pubmed-article:11540050pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11540050pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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