| pubmed-article:11535547 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C0376571 | lld:lifeskim |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C1419240 | lld:lifeskim |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C0600493 | lld:lifeskim |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C0752046 | lld:lifeskim |
| pubmed-article:11535547 | lifeskim:mentions | umls-concept:C1742737 | lld:lifeskim |
| pubmed-article:11535547 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11535547 | pubmed:dateCreated | 2001-9-5 | lld:pubmed |
| pubmed-article:11535547 | pubmed:abstractText | RAD51 colocalizes with both BRCA1 and BRCA2, and genetic variants in RAD51 would be candidate BRCA1/2 modifiers. We searched for RAD51 polymorphisms by sequencing 20 individuals. We compared the polymorphism allele frequencies between female BRCA1/2 mutation carriers with and without breast or ovarian cancer and between population-based ovarian cancer cases with BRCA1/2 mutations to cases and controls without mutations. We discovered two single nucleotide polymorphisms (SNPs) at positions 135 g-->c and 172 g-->t of the 5' untranslated region. In an initial group of BRCA1/2 mutation carriers, 14 (21%) of 67 breast cancer cases carried a "c" allele at RAD51:135 g-->c, whereas 8 (7%) of 119 women without breast cancer carried this allele. In a second set of 466 mutation carriers from three centers, the association of RAD51:135 g-->c with breast cancer risk was not confirmed. Analyses restricted to the 216 BRCA2 mutation carriers, however, showed a statistically significant association of the 135 "c" allele with the risk of breast cancer (adjusted odds ratio, 3.2; 95% confidence limit, 1.4-40). BRCA1/2 mutation carriers with ovarian cancer were only about one half as likely to carry the RAD51:135 g-->c SNP. Analysis of the RAD51:135 g-->c SNP in 738 subjects from an Israeli ovarian cancer case-control study was consistent with a lower risk of ovarian cancer among BRCA1/2 mutation carriers with the "c" allele. We have identified a RAD51 5' untranslated region SNP that may be associated with an increased risk of breast cancer and a lower risk of ovarian cancer among BRCA2 mutation carriers. The biochemical basis of this risk modifier is currently unknown. | lld:pubmed |
| pubmed-article:11535547 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11535547 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11535547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11535547 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11535547 | pubmed:issn | 1055-9965 | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:TuckerM AMA | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:ModanBB | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:TaroneR ERE | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:DalyMM | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:BovaFF | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:GodwinA KAK | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:LevaviHH | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:OffitKK | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:Chenevix-Tren... | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:StruewingJ... | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:SpurdleA BAB | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:DoodyM MMM | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:ChetritAA | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:KolachanaPP | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:WangW WWW | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:SuthersGG | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:KaufmanD JDJ | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:PierceHH | lld:pubmed |
| pubmed-article:11535547 | pubmed:author | pubmed-author:YechezkelG... | lld:pubmed |
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| pubmed-article:11535547 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11535547 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:11535547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11535547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11535547 | pubmed:pagination | 955-60 | lld:pubmed |
| pubmed-article:11535547 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11535547 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11535547 | pubmed:articleTitle | A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. | lld:pubmed |
| pubmed-article:11535547 | pubmed:affiliation | Laboratory of Population Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:11535547 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11535547 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:11535547 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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