| pubmed-article:11533249 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11533249 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11533249 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:11533249 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11533249 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:11533249 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:11533249 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11533249 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:11533249 | pubmed:dateCreated | 2001-9-4 | lld:pubmed |
| pubmed-article:11533249 | pubmed:abstractText | Signal transducer and activator of transcription 3 (STAT3) mediates signals of various growth factors and cytokines, including interleukin-6 (IL-6). In certain IL-6-responsive cell lines, the stat3 gene is autoregulated by STAT3 through a composite IL-6 response element in its promoter that contains a STAT3-binding element (SBE) and a cyclic AMP-responsive element. To reveal the nature and roles of the stat3 autoregulation in vivo, we generated mice that harbor a mutation in the SBE (stat3(mSBE)). The intact SBE was crucial for IL-6-induced stat3 gene activation in the spleen, especially in the red pulp region, the kidney, and both mature and immature T lymphocytes. The SBE was not required, however, for IL-6-induced stat3 gene activation in hepatocytes. T lymphocytes from the stat3(mSBE/mSBE) mice were more susceptible to apoptosis despite the presence of IL-6 than those from wild-type mice. Consistent with this, IL-6-dependent activation of the Pim-1 and junB genes, direct target genes for STAT3, was attenuated in T lymphocytes of the stat3(mSBE/mSBE) mice. Thus, the tissue-specific autoregulation of the stat3 gene operates in vivo and plays a role in IL-6-induced antiapoptotic signaling in T cells. | lld:pubmed |
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| pubmed-article:11533249 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11533249 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11533249 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11533249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11533249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11533249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11533249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11533249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11533249 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11533249 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11533249 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11533249 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:NakajimaKK | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:MaedaHH | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:ItohSS | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:HiranoTT | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:MizunoKK | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:ItohMM | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:IshiharaKK | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:NishidaKK | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:OhtaniTT | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:AtsumiTT | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:MiyazakiJJ | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:ParkS JSJ | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:HibiMM | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:NarimatsuMM | lld:pubmed |
| pubmed-article:11533249 | pubmed:author | pubmed-author:KamimuraDD | lld:pubmed |
| pubmed-article:11533249 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11533249 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11533249 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11533249 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11533249 | pubmed:pagination | 6615-25 | lld:pubmed |
| pubmed-article:11533249 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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