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pubmed-article:11532993pubmed:abstractTextWe report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.lld:pubmed
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pubmed-article:11532993pubmed:affiliationDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.lld:pubmed
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