| pubmed-article:11518731 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C0178987 | lld:lifeskim |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:11518731 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:11518731 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11518731 | pubmed:dateCreated | 2001-8-23 | lld:pubmed |
| pubmed-article:11518731 | pubmed:abstractText | The objective of this study was to investigate the contribution of secondary lymphoid organs in the generation and maintenance of experimental allergic airway inflammation. We employed a previously reported murine model of respiratory mucosal allergic sensitization, induced by repeated aerosolizations of ovalbumin in the context of a GM-CSF airway environment. We executed this protocol in wild-type (WT) and lymphotoxin-alpha-deficient mice (LTalpha-KO) mice, which are devoid of lymph nodes (LNs) and possess rudimentary spleen structures. Despite the lack of pulmonary LNs draining the airway compartment, LTalpha-KO mice were fully capable of mounting a robust inflammatory response in the airways, consisting of Th2 polarized CD4+ T cells and eosinophils. This was accompanied by IL-5, IL-13, and IFN-gamma production by splenocytes and generation of ovalbumin-specific serum IgE. Exposure to the same antigen 7 weeks after complete resolution of airway inflammation once again induced a Th2 polarized infiltrate, demonstrating intact immunological memory. To investigate inherent plasticity in establishing antigen-specific immunity, mice were splenectomized before sensitization. Allergic sensitization was completely abrogated in splenectomized LTalpha-KO mice, compared with eusplenic LTalpha-KO controls. These data demonstrate that secondary lymphoid organs, either LN or spleen, are essential for the generation of allergic airway responses. | lld:pubmed |
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| pubmed-article:11518731 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11518731 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11518731 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11518731 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11518731 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11518731 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:AlvarezDD | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:Gutierrez-Ram... | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:JordanaMM | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:CoyleA JAJ | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:StämpfliM RMR | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:GajewskaB UBU | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:VidricMM | lld:pubmed |
| pubmed-article:11518731 | pubmed:author | pubmed-author:GoncharovaSS | lld:pubmed |
| pubmed-article:11518731 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11518731 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:11518731 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11518731 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11518731 | pubmed:pagination | 577-83 | lld:pubmed |
| pubmed-article:11518731 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11518731 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11518731 | pubmed:articleTitle | Generation of experimental allergic airways inflammation in the absence of draining lymph nodes. | lld:pubmed |
| pubmed-article:11518731 | pubmed:affiliation | Department of Pathology and Molecular Medicine, and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada. | lld:pubmed |
| pubmed-article:11518731 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11518731 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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