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pubmed-article:11517387pubmed:abstractTextA number of diseases affecting the CNS occur in the dog and can be used as models for gene therapy in a large brain. HSV-1 has several potential advantages as a vector to transfer genes into the CNS. However, the ability of HSV-1 to infect CNS cells varies among species and no information was available for the dog. When the nonpathogenic 1716 strain of HSV-1 was injected into the brains of normal dogs it established a latent infection without signs of pathology. Thus, it appears to be suitable as a vector for therapeutic, or marker genes, in this species.lld:pubmed
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pubmed-article:11517387pubmed:authorpubmed-author:WolfeJ HJHlld:pubmed
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pubmed-article:11517387pubmed:pagination149-54lld:pubmed
pubmed-article:11517387pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11517387pubmed:articleTitleInfection and establishment of latency in the dog brain after direct inoculation of a nonpathogenic strain of herpes simplex virus-1.lld:pubmed
pubmed-article:11517387pubmed:affiliationDepartment of Pathobiology and Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.lld:pubmed
pubmed-article:11517387pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11517387pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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