| pubmed-article:11510978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C0027763 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C0205183 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11510978 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11510978 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11510978 | pubmed:dateCreated | 2001-8-20 | lld:pubmed |
| pubmed-article:11510978 | pubmed:abstractText | This study aims to investigate whether the immunohistochemical expression of galectin-8 could be used as a diagnostic marker in tumor tissues of various histogenetic origins including specimens from epithelial (n=145), mesenchymatous (n=16), adipous (n=10) and central and peripheral nervous system (n=25) tissue, and 4 mesotheliomas. Immunohistochemical reactions were carried out with a polyclonal anti-galectin-8 antibody and histological slides from tissues derived from the files of the Laboratory of Anatomopathology of University Erasmus Hospital, Brussels. Formalin-fixed paraffin-embedded tissues of 45 normal cases as well as 41 benign and 114 malignant tumors were studied. Marked decreases in immunohistochemical galectin-8 expression were observed in colon (p=0.001), pancreas (p=0.007), liver (p=0.0008), skin (p=0.002) and larynx (p=0.02) tissue when comparing malignant tissue to normal tissue and/or benign tumors. The reverse relationship was observed for breast tissue (p=0.007). No statistically significant differences (p>0.05) were detected when comparing normal tissue and/or benign to malignant tumors in lung, bladder, kidney, prostate and stomach tissue. Significant galectin-8 expression was also measured in non-epithelial tissue including tumors of the central and peripheral nervous system as well as in skeletal muscle and mesotheliomas. Immunohistochemical monitoring of galectin-8 thus reveals an organ-type-dependent regulation of expression upon malignant transformation of various tissue types of epithelial origin. This observation will prompt further studies to delineate any relationship with prognosis. | lld:pubmed |
| pubmed-article:11510978 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11510978 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11510978 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11510978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11510978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11510978 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11510978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11510978 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11510978 | pubmed:issn | 0213-3911 | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:GorenRR | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:KissRR | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:DanguyAA | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:PeteinMM | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:SalmonII | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:GabiusH JHJ | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:HadariY RYR | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:KaltnerHH | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:DecaesteckerC... | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:RoriveSS | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:BronckartYY | lld:pubmed |
| pubmed-article:11510978 | pubmed:author | pubmed-author:ZichYY | lld:pubmed |
| pubmed-article:11510978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11510978 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:11510978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11510978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11510978 | pubmed:pagination | 861-8 | lld:pubmed |
| pubmed-article:11510978 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11510978 | pubmed:meshHeading | pubmed-meshheading:11510978... | lld:pubmed |
| pubmed-article:11510978 | pubmed:meshHeading | pubmed-meshheading:11510978... | lld:pubmed |
| pubmed-article:11510978 | pubmed:meshHeading | pubmed-meshheading:11510978... | lld:pubmed |
| pubmed-article:11510978 | pubmed:meshHeading | pubmed-meshheading:11510978... | lld:pubmed |
| pubmed-article:11510978 | pubmed:meshHeading | pubmed-meshheading:11510978... | lld:pubmed |
| pubmed-article:11510978 | pubmed:meshHeading | pubmed-meshheading:11510978... | lld:pubmed |
| pubmed-article:11510978 | pubmed:meshHeading | pubmed-meshheading:11510978... | lld:pubmed |
| pubmed-article:11510978 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11510978 | pubmed:articleTitle | Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous system. | lld:pubmed |
| pubmed-article:11510978 | pubmed:affiliation | Laboratory of Histopathology, Faculty of Medicine, Université Libre de Bruxelles, Belgium. | lld:pubmed |
| pubmed-article:11510978 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11510978 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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