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pubmed-article:11509287pubmed:abstractTextCardiopulmonary bypass (CPB) surgery induces a transient rise in pro-inflammatory cytokines typically released by activated monocytes. The E4 variant of apolipoprotein E is a recognized risk factor for atherosclerosis. It has recently been shown that apolipoprotein E affects monocyte functions in vitro and leads to higher levels of median lipoprotein (a) in humans. The aim of the study is to investigate if the E4 genetic variant of apolipoprotein E affects cytokine release after CPB surgery.lld:pubmed
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pubmed-article:11509287pubmed:articleTitleGenetic predisposition in patients undergoing cardiopulmonary bypass surgery is associated with an increase of inflammatory cytokines.lld:pubmed
pubmed-article:11509287pubmed:affiliationClinic for Cardiovascular Surgery, University Hospital Zürich, Zürich, Switzerland.lld:pubmed
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