| pubmed-article:11502581 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11502581 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11502581 | lifeskim:mentions | umls-concept:C0221464 | lld:lifeskim |
| pubmed-article:11502581 | lifeskim:mentions | umls-concept:C0070876 | lld:lifeskim |
| pubmed-article:11502581 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:11502581 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:11502581 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:11502581 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11502581 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11502581 | pubmed:dateCreated | 2001-8-14 | lld:pubmed |
| pubmed-article:11502581 | pubmed:abstractText | Phospholamban (PLB) inhibits the sarcoplasmic reticulum (SR) Ca(2+)-ATPase, and this inhibition is relieved by cAMP-dependent protein kinase (PKA)-mediated phosphorylation. The role of PLB in regulating Ca(2+) release through ryanodine-sensitive Ca(2+) release channels, measured as Ca(2+) sparks, was examined using smooth muscle cells of cerebral arteries from PLB-deficient ("knockout") mice (PLB-KO). Ca(2+) sparks were monitored optically using the fluorescent Ca(2+) indicator fluo 3 or electrically by measuring transient large-conductance Ca(2+)-activated K(+) (BK) channel currents activated by Ca(2+) sparks. Basal Ca(2+) spark and transient BK current frequency were elevated in cerebral artery myocytes of PLB-KO mice. Forskolin, an activator of adenylyl cyclase, increased the frequency of Ca(2+) sparks and transient BK currents in cerebral arteries from control mice. However, forskolin had little effect on the frequency of Ca(2+) sparks and transient BK currents from PLB-KO cerebral arteries. Forskolin or PLB-KO increased SR Ca(2+) load, as measured by caffeine-induced Ca(2+) transients. This study provides the first evidence that PLB is critical for frequency modulation of Ca(2+) sparks and associated BK currents by PKA in smooth muscle. | lld:pubmed |
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| pubmed-article:11502581 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11502581 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11502581 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11502581 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11502581 | pubmed:issn | 0363-6143 | lld:pubmed |
| pubmed-article:11502581 | pubmed:author | pubmed-author:NelsonM TMT | lld:pubmed |
| pubmed-article:11502581 | pubmed:author | pubmed-author:SantanaL FLF | lld:pubmed |
| pubmed-article:11502581 | pubmed:author | pubmed-author:WellmanG CGC | lld:pubmed |
| pubmed-article:11502581 | pubmed:author | pubmed-author:BonevA DAD | lld:pubmed |
| pubmed-article:11502581 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11502581 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:11502581 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11502581 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11502581 | pubmed:pagination | C1029-37 | lld:pubmed |
| pubmed-article:11502581 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11502581 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11502581 | pubmed:articleTitle | Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMP. | lld:pubmed |
| pubmed-article:11502581 | pubmed:affiliation | Department of Pharmacology, University of Vermont, Burlington, Vermont 05405, USA. | lld:pubmed |
| pubmed-article:11502581 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11502581 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11502581 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11502581 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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