pubmed-article:11498255 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11498255 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
pubmed-article:11498255 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:11498255 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
pubmed-article:11498255 | lifeskim:mentions | umls-concept:C0017070 | lld:lifeskim |
pubmed-article:11498255 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:11498255 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:11498255 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:11498255 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:11498255 | pubmed:dateCreated | 2001-8-10 | lld:pubmed |
pubmed-article:11498255 | pubmed:abstractText | The expression of interleukin-1beta was examined in dorsal root ganglion (DRG) neurons from adult rats using non-radioactive in situ hybridization and immunocytochemistry. At all spinal levels, approximately 70% of the DRG neurons appeared to express IL-1beta mRNA; about 80% of these DRG neurons actually appeared to produce the IL-1beta protein at markedly varying levels. The expression of IL-1beta was found in large as well as in intermediate diameter sensory neurons but only sporadically in the population of small sensory neurons. The population of IL-1beta immunopositive sensory neurons included most of the large calretinin-positive Ia afferents, but only a few of the small substance P/CGRP positive sensory neurons. In situ hybridization staining for the detection of type 1 IL-1 receptor showed expression of this receptor by most of the sensory neurons as well as by supportive glial-like cells, presumably satellite cells. The functional significance of IL-1beta in the DRG neurons needs to be elucidated, but we speculate that IL-1beta produced by DRG neurons may be an auto/paracrine signalling molecule in sensory transmission. | lld:pubmed |
pubmed-article:11498255 | pubmed:language | eng | lld:pubmed |
pubmed-article:11498255 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11498255 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11498255 | pubmed:month | Aug | lld:pubmed |
pubmed-article:11498255 | pubmed:issn | 0165-5728 | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:TildersF JFJ | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:BoddekeH WHW | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:HuitingaII | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:BrouwerNN | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:LiemR SRS | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:CoprayJ CJC | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:Van DamA MAM | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:BiberKK | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:KüstB MBM | lld:pubmed |
pubmed-article:11498255 | pubmed:author | pubmed-author:MantinghII | lld:pubmed |
pubmed-article:11498255 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11498255 | pubmed:day | 30 | lld:pubmed |
pubmed-article:11498255 | pubmed:volume | 118 | lld:pubmed |
pubmed-article:11498255 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11498255 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11498255 | pubmed:pagination | 203-11 | lld:pubmed |
pubmed-article:11498255 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:11498255 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11498255 | pubmed:articleTitle | Expression of interleukin-1 beta in rat dorsal root ganglia. | lld:pubmed |
pubmed-article:11498255 | pubmed:affiliation | Department of Medical Physiology, University of Groningen, A. Deusinglaan 1, Bloemsingel 10, 9713 AV KZ, Groningen, Netherlands. j.c.v.m.copray@med.rug.nl | lld:pubmed |
pubmed-article:11498255 | pubmed:publicationType | Journal Article | lld:pubmed |
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