| pubmed-article:11494361 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C2333134 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C1415288 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:11494361 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11494361 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11494361 | pubmed:dateCreated | 2001-8-8 | lld:pubmed |
| pubmed-article:11494361 | pubmed:abstractText | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R)-mediated neurotoxicity was studied in relation to subunit expression and the presence of Ca(2+)-permeable receptor channels. AMPA-mediated toxicity had two components: 1) a direct AMPA-R-mediated component, which was not due to Ca(2+) influx through voltage-gated Ca(2+) channels, reversal of the Na(+)/Ca(2+) exchanger or release of calcium from dantrolene-sensitive intracellular Ca(2+) stores, and 2) a minor, indirect component involving activation of NMDA receptor channels, because of glutamate release and removal of the Mg(2+) block of the NMDA receptor on AMPA-R stimulation. The involvement of Ca(2+) influx through AMPA-R was also examined. The number of neurons possessing Ca(2+)-permeable AMPA-R increased during culture development, concurrently with an increasing susceptibility for AMPA-induced toxicity during development. GluR2(R) levels also increased during development, and channel blockers of Ca(2+)-permeable AMPA-R lacking the GluR2(R) subunit (spermine and philanthotoxin) failed to prevent neurotoxicity or increases in [Ca(2+)](i). Thus, the direct AMPA-R-mediated toxicity may be explained by initiation of cell death by Ca(2+) fluxing through AMPA-R containing GluR2(R). The components of direct AMPA-R-mediated toxicity are proposed to be 1) toxicity mediated by GluR2(R)-lacking AMPA-R and 2) toxicity mediated by low-Ca(2+)-permeability AMPA-R containing GluR2(R). | lld:pubmed |
| pubmed-article:11494361 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11494361 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11494361 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11494361 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11494361 | pubmed:issn | 0360-4012 | lld:pubmed |
| pubmed-article:11494361 | pubmed:author | pubmed-author:SchousboeAA | lld:pubmed |
| pubmed-article:11494361 | pubmed:author | pubmed-author:JensenJ BJB | lld:pubmed |
| pubmed-article:11494361 | pubmed:author | pubmed-author:LundT MTM | lld:pubmed |
| pubmed-article:11494361 | pubmed:author | pubmed-author:PickeringD... | lld:pubmed |
| pubmed-article:11494361 | pubmed:author | pubmed-author:TimmermannD... | lld:pubmed |
| pubmed-article:11494361 | pubmed:copyrightInfo | Copyright 2001 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:11494361 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11494361 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11494361 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:11494361 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11494361 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11494361 | pubmed:pagination | 267-77 | lld:pubmed |
| pubmed-article:11494361 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:meshHeading | pubmed-meshheading:11494361... | lld:pubmed |
| pubmed-article:11494361 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11494361 | pubmed:articleTitle | Role of GluR2 expression in AMPA-induced toxicity in cultured murine cerebral cortical neurons. | lld:pubmed |
| pubmed-article:11494361 | pubmed:affiliation | The Royal Danish School of Pharmacy, NeuroScience PharmaBiotech Research Center, Department of Pharmacology, 2 Universitetsparken, DK-2100 Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:11494361 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11494361 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
