| pubmed-article:11490014 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11490014 | lifeskim:mentions | umls-concept:C0125090 | lld:lifeskim |
| pubmed-article:11490014 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:11490014 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11490014 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:11490014 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:11490014 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:11490014 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11490014 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11490014 | pubmed:dateCreated | 2001-8-7 | lld:pubmed |
| pubmed-article:11490014 | pubmed:abstractText | L-selectin is a calcium-dependent lectin on leukocytes mediating leukocyte rolling in high endothelial venules and inflamed microvessels. Many selectin ligands require modification of glycoproteins by leukocyte core2 beta1,6-N-acetylglucosaminyltransferase (Core2GlcNAcT-I). To test the role of Core2GlcNAcT-I for L-selectin ligand biosynthesis, we investigated leukocyte rolling in venules of untreated and TNF-alpha-treated cremaster muscles and in Peyer's patch high endothelial venules (HEV) of Core2GlcNAcT-I null (core2(-/-)) mice. In the presence of blocking mAbs against P- and E-selectin, L-selectin-mediated leukocyte rolling was almost completely abolished in cremaster muscle venules of core2(-/-) mice, but not littermate control mice. By contrast, leukocyte rolling in Peyer's patch HEV was not significantly different between core2(-/-) and control mice. To probe L-selectin ligands more directly, we injected L-selectin-coated beads. These beads showed no rolling in cremaster muscle venules of core2(-/-) mice, but significant rolling in controls. In Peyer's patch HEV, beads coated with a low concentration of L-selectin showed reduced rolling in core2(-/-) mice. Beads coated with a 10-fold higher concentration of L-selectin rolled equivalently in core2(-/-) and control mice. Our data show that endothelial L-selectin ligands relevant for rolling in inflamed microvessels of the cremaster muscle are completely Core2GlcNAcT-I dependent. In contrast, L-selectin ligands in Peyer's patch HEV are only marginally affected by the absence of Core2GlcNAcT-I, but are sufficiently functional to support L-selectin-dependent leukocyte rolling in Core2GlcNAcT-I-deficient mice. | lld:pubmed |
| pubmed-article:11490014 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11490014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11490014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11490014 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11490014 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11490014 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11490014 | pubmed:author | pubmed-author:RaevuoriMM | lld:pubmed |
| pubmed-article:11490014 | pubmed:author | pubmed-author:ElliesL GLG | lld:pubmed |
| pubmed-article:11490014 | pubmed:author | pubmed-author:LeyKK | lld:pubmed |
| pubmed-article:11490014 | pubmed:author | pubmed-author:SperandioMM | lld:pubmed |
| pubmed-article:11490014 | pubmed:author | pubmed-author:ThatteJJ | lld:pubmed |
| pubmed-article:11490014 | pubmed:author | pubmed-author:ForlowS BSB | lld:pubmed |
| pubmed-article:11490014 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11490014 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11490014 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11490014 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11490014 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11490014 | pubmed:pagination | 2268-74 | lld:pubmed |
| pubmed-article:11490014 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11490014 | pubmed:meshHeading | pubmed-meshheading:11490014... | lld:pubmed |
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| pubmed-article:11490014 | pubmed:meshHeading | pubmed-meshheading:11490014... | lld:pubmed |
| pubmed-article:11490014 | pubmed:meshHeading | pubmed-meshheading:11490014... | lld:pubmed |
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| pubmed-article:11490014 | pubmed:meshHeading | pubmed-meshheading:11490014... | lld:pubmed |
| pubmed-article:11490014 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11490014 | pubmed:articleTitle | Differential requirements for core2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo. | lld:pubmed |
| pubmed-article:11490014 | pubmed:affiliation | Department of Biomedical Engineering, and Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA. | lld:pubmed |
| pubmed-article:11490014 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11490014 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11490014 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14537 | entrezgene:pubmed | pubmed-article:11490014 | lld:entrezgene |
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