| pubmed-article:11488598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11488598 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11488598 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:11488598 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:11488598 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:11488598 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11488598 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11488598 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11488598 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11488598 | pubmed:dateCreated | 2001-8-7 | lld:pubmed |
| pubmed-article:11488598 | pubmed:abstractText | To clarify the mechanism of apoptosis of the macrophage-like cell line RAW264.7 induced by cationic liposomes, we focused on the mitochondria and investigated the changes in mitochondrial membrane potential and the release of cytochrome c following treatment of cationic liposomes composed of stearylamine (SA-liposomes). SA-liposomes induced mitochondrial membrane depolarization and also the release of cytochrome c from mitochondria. Caspase-3 was also activated by SA-liposome treatment. Pretreatment of cells with N-acetylcysteine, a scavenger of reactive oxygen species (ROS), conferred resistance to the induction of the membrane depolarization, cytochrome c release, and caspase-3 activation by SA-liposomes. These results indicated that SA-liposomes caused the apoptosis in RAW264.7 cells through the mitochondrial pathway, and ROS generation was required for this phenomenon. | lld:pubmed |
| pubmed-article:11488598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11488598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11488598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11488598 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11488598 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:11488598 | pubmed:author | pubmed-author:AramakiYY | lld:pubmed |
| pubmed-article:11488598 | pubmed:author | pubmed-author:TakanoSS | lld:pubmed |
| pubmed-article:11488598 | pubmed:author | pubmed-author:TsuchiyaSS | lld:pubmed |
| pubmed-article:11488598 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11488598 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11488598 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11488598 | pubmed:volume | 392 | lld:pubmed |
| pubmed-article:11488598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11488598 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11488598 | pubmed:pagination | 245-50 | lld:pubmed |
| pubmed-article:11488598 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:meshHeading | pubmed-meshheading:11488598... | lld:pubmed |
| pubmed-article:11488598 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11488598 | pubmed:articleTitle | Cationic liposomes induce macrophage apoptosis through mitochondrial pathway. | lld:pubmed |
| pubmed-article:11488598 | pubmed:affiliation | School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. aramaki@ps.toyaku.ac.jp | lld:pubmed |
| pubmed-article:11488598 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11488598 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11488598 | lld:pubmed |
