| pubmed-article:11483588 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11483588 | lifeskim:mentions | umls-concept:C1235660 | lld:lifeskim |
| pubmed-article:11483588 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:11483588 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:11483588 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:11483588 | lifeskim:mentions | umls-concept:C1335532 | lld:lifeskim |
| pubmed-article:11483588 | lifeskim:mentions | umls-concept:C2353566 | lld:lifeskim |
| pubmed-article:11483588 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:11483588 | pubmed:dateCreated | 2001-9-17 | lld:pubmed |
| pubmed-article:11483588 | pubmed:abstractText | The intramembrane cleavage of beta-amyloid precursor protein by gamma-secretase is the final step in the generation of amyloid beta-protein. A 59- or 57-residue C-terminal fragment called CTFgamma is produced concomitantly. Putative CTFgamma generated in rat brain membrane preparations was purified and sequenced. Instead of CTFgamma, shorter 50- and 49-residue fragments were identified. In addition, we found similar C-terminal fragments of beta-amyloid precursor-like proteins 1 and 2; these were also cleaved at corresponding sites. This newly identified cleavage occurs at a site two to five residues inside the cytoplasmic membrane boundary, which is very similar to gamma-secretase-like cleavage of Notch 1. | lld:pubmed |
| pubmed-article:11483588 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11483588 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483588 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11483588 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11483588 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483588 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11483588 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11483588 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11483588 | pubmed:author | pubmed-author:SatoTT | lld:pubmed |
| pubmed-article:11483588 | pubmed:author | pubmed-author:DohmaeNN | lld:pubmed |
| pubmed-article:11483588 | pubmed:author | pubmed-author:IharaYY | lld:pubmed |
| pubmed-article:11483588 | pubmed:author | pubmed-author:TakioKK | lld:pubmed |
| pubmed-article:11483588 | pubmed:author | pubmed-author:FOXJ NJN | lld:pubmed |
| pubmed-article:11483588 | pubmed:author | pubmed-author:MisonouHH | lld:pubmed |
| pubmed-article:11483588 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11483588 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:11483588 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11483588 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11483588 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11483588 | pubmed:pagination | 35235-8 | lld:pubmed |
| pubmed-article:11483588 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11483588 | pubmed:meshHeading | pubmed-meshheading:11483588... | lld:pubmed |
| pubmed-article:11483588 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11483588 | pubmed:articleTitle | Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. | lld:pubmed |
| pubmed-article:11483588 | pubmed:affiliation | Department of Neuropathology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. | lld:pubmed |
| pubmed-article:11483588 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11483588 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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