| pubmed-article:11483520 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11483520 | lifeskim:mentions | umls-concept:C0796520 | lld:lifeskim |
| pubmed-article:11483520 | lifeskim:mentions | umls-concept:C0598766 | lld:lifeskim |
| pubmed-article:11483520 | lifeskim:mentions | umls-concept:C0920533 | lld:lifeskim |
| pubmed-article:11483520 | lifeskim:mentions | umls-concept:C0314672 | lld:lifeskim |
| pubmed-article:11483520 | lifeskim:mentions | umls-concept:C1519124 | lld:lifeskim |
| pubmed-article:11483520 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:11483520 | pubmed:dateCreated | 2001-8-2 | lld:pubmed |
| pubmed-article:11483520 | pubmed:abstractText | TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome. | lld:pubmed |
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| pubmed-article:11483520 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11483520 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483520 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11483520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11483520 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483520 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11483520 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11483520 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:KinHH | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:RoseTT | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:PhillipsM LML | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:RobinsonM AMA | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:BowieJ UJU | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:KimC ACA | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:FahamSS | lld:pubmed |
| pubmed-article:11483520 | pubmed:author | pubmed-author:GingeryMM | lld:pubmed |
| pubmed-article:11483520 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11483520 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11483520 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11483520 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11483520 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11483520 | pubmed:pagination | 4173-82 | lld:pubmed |
| pubmed-article:11483520 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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