| pubmed-article:11483504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11483504 | lifeskim:mentions | umls-concept:C0143630 | lld:lifeskim |
| pubmed-article:11483504 | lifeskim:mentions | umls-concept:C0077678 | lld:lifeskim |
| pubmed-article:11483504 | lifeskim:mentions | umls-concept:C1366480 | lld:lifeskim |
| pubmed-article:11483504 | lifeskim:mentions | umls-concept:C1417663 | lld:lifeskim |
| pubmed-article:11483504 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:11483504 | pubmed:dateCreated | 2001-8-2 | lld:pubmed |
| pubmed-article:11483504 | pubmed:abstractText | NEDD8/Rub1 is a ubiquitin (Ub)-like post-translational modifier that is covalently linked to cullin (Cul)-family proteins in a manner analogous to ubiquitylation. NEDD8 is known to enhance the ubiquitylating activity of the SCF complex (composed of Skp1, Cul-1, ROC1 and F-box protein), but the mechanistic role is largely unknown. Using an in vitro reconstituted system, we report here that NEDD8 modification of Cul-1 enhances recruitment of Ub-conjugating enzyme Ubc4 (E2) to the SCF complex (E3). This recruitment requires thioester linkage of Ub to Ubc4. Our findings indicate that the NEDD8-modifying system accelerates the formation of the E2-E3 complex, which stimulates protein polyubiquitylation. | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11483504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11483504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11483504 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11483504 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:SuzukiTT | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:TanakaKK | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:SuzukiHH | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:IwaiKK | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:ChibaTT | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:MinatoNN | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:KawakamiTT | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:YamanakaKK | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:OmataMM | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:HidakaYY | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:OsakiNN | lld:pubmed |
| pubmed-article:11483504 | pubmed:author | pubmed-author:ShimbaraNN | lld:pubmed |
| pubmed-article:11483504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11483504 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11483504 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11483504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11483504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11483504 | pubmed:pagination | 4003-12 | lld:pubmed |
| pubmed-article:11483504 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:meshHeading | pubmed-meshheading:11483504... | lld:pubmed |
| pubmed-article:11483504 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11483504 | pubmed:articleTitle | NEDD8 recruits E2-ubiquitin to SCF E3 ligase. | lld:pubmed |
| pubmed-article:11483504 | pubmed:affiliation | Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. | lld:pubmed |
| pubmed-article:11483504 | pubmed:publicationType | Journal Article | lld:pubmed |
