| pubmed-article:11477408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11477408 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:11477408 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:11477408 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:11477408 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11477408 | lifeskim:mentions | umls-concept:C1518071 | lld:lifeskim |
| pubmed-article:11477408 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:11477408 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11477408 | pubmed:dateCreated | 2001-7-30 | lld:pubmed |
| pubmed-article:11477408 | pubmed:abstractText | Estrogen is a negative regulator of lymphopoiesis and provides an experimental tool for probing relationships between lymphocyte precursors and stem cells. We found that expression of lymphocyte-associated genes and immunoglobulin (Ig) gene rearrangement occurred before CD45R acquisition. Lymphoid-restricted progenitors that were Lin(-)IL-7R alpha(+)c-kit(lo)TdT(+) (lineage marker(-), interleukin receptor 7 alpha(+), c-kit(lo) and terminal deoxynucleotidyl transferase(+)) were selectively depleted in estrogen-treated mice; within a less differentiated Lin-c-kit(hi) fraction, functional precursors of B and T, but not myeloid, cells were also selectively depleted. TdT and an Ig heavy chain transgene were detected within a hormone-regulated Lin(-)c-kit(hi)Sca-1(+)CD27(+)Flk-2(+)IL-7R alpha(-) subset of this multipotential progenitor population. Identification of these extremely early lymphoid precursors should facilitate investigation of the molecular mechanisms that control lineage-fate decisions in hematopoiesis. | lld:pubmed |
| pubmed-article:11477408 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11477408 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11477408 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11477408 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11477408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11477408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11477408 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11477408 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:11477408 | pubmed:author | pubmed-author:KincadeP WPW | lld:pubmed |
| pubmed-article:11477408 | pubmed:author | pubmed-author:ThompsonL FLF | lld:pubmed |
| pubmed-article:11477408 | pubmed:author | pubmed-author:PayneK JKJ | lld:pubmed |
| pubmed-article:11477408 | pubmed:author | pubmed-author:GarrettK PKP | lld:pubmed |
| pubmed-article:11477408 | pubmed:author | pubmed-author:MedinaK LKL | lld:pubmed |
| pubmed-article:11477408 | pubmed:author | pubmed-author:RossiM IMI | lld:pubmed |
| pubmed-article:11477408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11477408 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:11477408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11477408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11477408 | pubmed:pagination | 718-24 | lld:pubmed |
| pubmed-article:11477408 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11477408 | pubmed:meshHeading | pubmed-meshheading:11477408... | lld:pubmed |
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| pubmed-article:11477408 | pubmed:meshHeading | pubmed-meshheading:11477408... | lld:pubmed |
| pubmed-article:11477408 | pubmed:meshHeading | pubmed-meshheading:11477408... | lld:pubmed |
| pubmed-article:11477408 | pubmed:meshHeading | pubmed-meshheading:11477408... | lld:pubmed |
| pubmed-article:11477408 | pubmed:meshHeading | pubmed-meshheading:11477408... | lld:pubmed |
| pubmed-article:11477408 | pubmed:meshHeading | pubmed-meshheading:11477408... | lld:pubmed |
| pubmed-article:11477408 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11477408 | pubmed:articleTitle | Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. | lld:pubmed |
| pubmed-article:11477408 | pubmed:affiliation | Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104, USA. | lld:pubmed |
| pubmed-article:11477408 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11477408 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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