| pubmed-article:11470822 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11470822 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:11470822 | lifeskim:mentions | umls-concept:C1176286 | lld:lifeskim |
| pubmed-article:11470822 | lifeskim:mentions | umls-concept:C0526999 | lld:lifeskim |
| pubmed-article:11470822 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:11470822 | lifeskim:mentions | umls-concept:C0237477 | lld:lifeskim |
| pubmed-article:11470822 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11470822 | lifeskim:mentions | umls-concept:C1438442 | lld:lifeskim |
| pubmed-article:11470822 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11470822 | pubmed:dateCreated | 2001-7-25 | lld:pubmed |
| pubmed-article:11470822 | pubmed:abstractText | Adenovirus early region 4 open reading frame 4 (E4orf4) protein has been reported to induce p53-independent, protein phosphatase 2A (PP2A)-dependent apoptosis in transformed mammalian cells. In this report, we show that E4orf4 induces an irreversible growth arrest in Saccharomyces cerevisiae at the G2/M phase of the cell cycle. Growth inhibition requires the presence of yeast PP2A-Cdc55, and is accompanied by accumulation of reactive oxygen species. E4orf4 expression is synthetically lethal with mutants defective in mitosis, including Cdc28/Cdk1 and anaphase-promoting complex/cyclosome (APC/C) mutants. Although APC/C activity is inhibited in the presence of E4orf4, Cdc28/Cdk1 is activated and partially counteracts the E4orf4-induced cell cycle arrest. The E4orf4-PP2A complex physically interacts with the APC/C, suggesting that E4orf4 functions by directly targeting PP2A to the APC/C, thereby leading to its inactivation. Finally, we show that E4orf4 can induce G2/M arrest in mammalian cells before apoptosis, indicating that E4orf4-induced events in yeast and mammalian cells are highly conserved. | lld:pubmed |
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| pubmed-article:11470822 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11470822 | pubmed:citationSubset | IM | lld:pubmed |
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