| pubmed-article:11466347 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C1335874 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C1167231 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C0205344 | lld:lifeskim |
| pubmed-article:11466347 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11466347 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11466347 | pubmed:dateCreated | 2001-7-23 | lld:pubmed |
| pubmed-article:11466347 | pubmed:abstractText | IL-12 and IL-18 are both proinflammatory cytokines that contribute to promoting Th1 development and IFN-gamma expression. However, neither IL-12R nor IL-18R is expressed as a functional complex on most resting T cells. This study investigated the molecular mechanisms underlying the induction of an IL-18R complex in T cells. Resting T cells expressed IL-18Ralpha chains but did not exhibit IL-18 binding sites as detected by incubation with rIL-18 followed by anti-IL-18 Ab, suggesting a lack of IL-18Rbeta expression in resting T cells. Although they also failed to express IL-12R, stimulation with anti-CD3 plus anti-CD28 generated IL-12R. Exposure of these cells to IL-12 led not only to up-regulation of IL-18Ralpha expression but also to induction of IL-18R binding sites on both CD4(+) and CD8(+) T cells concomitant with IL-18Rbeta mRNA expression. The IL-18 binding site represented a functional IL-18R complex capable of exhibiting IL-18 responsiveness. IL-12 induction of an IL-18R complex and IL-18Rbeta mRNA expression was not observed in STAT4-deficient (STAT4(-/-)) T cells and was substantially decreased in IFN-gamma(-/-) T cells. However, the failure of STAT4(-/-) T cells to induce an IL-18R complex was not corrected by IFN-gamma. These results indicate that STAT4 and IFN-gamma play an indispensable role and a role as an amplifying factor, respectively, in IL-12 induction of the functional IL-18R complex. | lld:pubmed |
| pubmed-article:11466347 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11466347 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466347 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11466347 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11466347 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:FujiwaraHH | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:HamaokaTT | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:OhtaTT | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:WooV LVL | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:IwasakiMM | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:KurimotoMM | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:TomuraMM | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:NakahiraMM | lld:pubmed |
| pubmed-article:11466347 | pubmed:author | pubmed-author:BianYY | lld:pubmed |
| pubmed-article:11466347 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11466347 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11466347 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11466347 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11466347 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11466347 | pubmed:pagination | 1306-12 | lld:pubmed |
| pubmed-article:11466347 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:meshHeading | pubmed-meshheading:11466347... | lld:pubmed |
| pubmed-article:11466347 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11466347 | pubmed:articleTitle | An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex. | lld:pubmed |
| pubmed-article:11466347 | pubmed:affiliation | Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:11466347 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11466347 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:15978 | entrezgene:pubmed | pubmed-article:11466347 | lld:entrezgene |
| entrez-gene:20849 | entrezgene:pubmed | pubmed-article:11466347 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11466347 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11466347 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11466347 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11466347 | lld:pubmed |
