| pubmed-article:11466322 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C0242358 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C1173313 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:11466322 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:11466322 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:11466322 | pubmed:dateCreated | 2001-9-17 | lld:pubmed |
| pubmed-article:11466322 | pubmed:abstractText | Interleukin (IL)-15 is able to regulate tight junction formation in intestinal epithelial cells. However, the mechanisms that regulate the intestinal barrier function in response to IL-15 and the involved subunits of the IL-15 ligand-receptor system are unknown. We determined the IL-2Rbeta subunit and IL-15-dependent regulation of tight junction-associated proteins in the human intestinal epithelial cell line T-84. The IL-2Rbeta subunit was expressed and induced signal transduction in caveolin enriched rafts in intestinal epithelial cells. IL-15-mediated tightening of intestinal epithelial monolayers correlated with the enhanced recruitment of tight junction proteins into Triton X-100-insoluble protein fractions. IL-15-mediated up-regulation of ZO-1 and ZO-2 expression was independent of the IL-2Rbeta subunit, whereas the phosphorylation of occludin and enhanced membrane association of claudin-1 and claudin-2 by IL-15 required the presence of the IL-2Rbeta subunit. Recruitment of claudins and hyperphosphorylated occludin into tight junctions resulted in a more marked induction of tight junction formation in intestinal epithelial cells than the up-regulation of ZO-1 and ZO-2 by itself. The regulation of the intestinal epithelial barrier function by IL-15 involves IL-2Rbeta-dependent and -independent signaling pathways leading to the recruitment of claudins, hyperphosphorylated occludin, ZO-1, and ZO-2 into the tight junctional protein complex. | lld:pubmed |
| pubmed-article:11466322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11466322 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11466322 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11466322 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11466322 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11466322 | pubmed:author | pubmed-author:MacDermottR... | lld:pubmed |
| pubmed-article:11466322 | pubmed:author | pubmed-author:PodolskyD KDK | lld:pubmed |
| pubmed-article:11466322 | pubmed:author | pubmed-author:KinugasaTT | lld:pubmed |
| pubmed-article:11466322 | pubmed:author | pubmed-author:SakaguchiTT | lld:pubmed |
| pubmed-article:11466322 | pubmed:author | pubmed-author:NishiyamaRR | lld:pubmed |
| pubmed-article:11466322 | pubmed:author | pubmed-author:LEEO KOK | lld:pubmed |
| pubmed-article:11466322 | pubmed:author | pubmed-author:ReineckerH... | lld:pubmed |
| pubmed-article:11466322 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11466322 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:11466322 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11466322 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11466322 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11466322 | pubmed:pagination | 35571-80 | lld:pubmed |
| pubmed-article:11466322 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
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| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:meshHeading | pubmed-meshheading:11466322... | lld:pubmed |
| pubmed-article:11466322 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11466322 | pubmed:articleTitle | Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. | lld:pubmed |
| pubmed-article:11466322 | pubmed:affiliation | Gastrointestinal Unit, Department of Medicine, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, USA. | lld:pubmed |
| pubmed-article:11466322 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11466322 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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