| pubmed-article:11448992 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0162832 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0080129 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0526999 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0694872 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11448992 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:11448992 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11448992 | pubmed:dateCreated | 2001-7-12 | lld:pubmed |
| pubmed-article:11448992 | pubmed:abstractText | Cell cycle progression is driven by waves of cyclin expression coupled with regulated protein degradation. An essential step for initiating mitosis is the inactivation of proteolysis mediated by the anaphase-promoting complex/cyclosome (APC/C) bound to its regulator Cdh1p/Hct1p. Yeast APC(Cdh1) was proposed previously to be inactivated at Start by G1 cyclin/cyclin-dependent kinase (CDK). Here, we demonstrate that in a normal cell cycle APC(Cdh1) is inactivated in a graded manner and is not extinguished until S phase. Complete inactivation of APC(Cdh1) requires S phase cyclins. Further, persistent APC(Cdh1) activity throughout G1 helps to ensure the proper timing of Cdc20p expression. This suggests that S phase cyclins have an important role in allowing the accumulation of mitotic cyclins and further suggests a regulatory loop among S phase cyclins, APC(Cdh1), and APC(Cdc20). | lld:pubmed |
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| pubmed-article:11448992 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11448992 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11448992 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11448992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11448992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11448992 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11448992 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11448992 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:11448992 | pubmed:author | pubmed-author:ParrRR | lld:pubmed |
| pubmed-article:11448992 | pubmed:author | pubmed-author:PellmanDD | lld:pubmed |
| pubmed-article:11448992 | pubmed:author | pubmed-author:HuangJ NJN | lld:pubmed |
| pubmed-article:11448992 | pubmed:author | pubmed-author:LittlepageL... | lld:pubmed |
| pubmed-article:11448992 | pubmed:author | pubmed-author:EllingsonEE | lld:pubmed |
| pubmed-article:11448992 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11448992 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:11448992 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:11448992 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11448992 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11448992 | pubmed:pagination | 85-94 | lld:pubmed |
| pubmed-article:11448992 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11448992 | pubmed:meshHeading | pubmed-meshheading:11448992... | lld:pubmed |
| pubmed-article:11448992 | pubmed:meshHeading | pubmed-meshheading:11448992... | lld:pubmed |
| pubmed-article:11448992 | pubmed:meshHeading | pubmed-meshheading:11448992... | lld:pubmed |
| pubmed-article:11448992 | pubmed:meshHeading | pubmed-meshheading:11448992... | lld:pubmed |
| pubmed-article:11448992 | pubmed:meshHeading | pubmed-meshheading:11448992... | lld:pubmed |
