| pubmed-article:11448776 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:11448776 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11448776 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11448776 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11448776 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:11448776 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:11448776 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:11448776 | pubmed:dateCreated | 2001-7-12 | lld:pubmed |
| pubmed-article:11448776 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11448776 | pubmed:abstractText | Ca(2+) is a universal second messenger that is critical for cell growth and is intimately associated with many Ras-dependent cellular processes such as proliferation and differentiation. Ras is a small GTP binding protein that operates as a molecular switch regulating the control of gene expression, cell growth, and differentiation through a pathway from receptors to mitogen-activated protein kinases (MAPKs). A role for intracellular Ca(2+) in the activation of Ras has been previously demonstrated, e.g., via the nonreceptor tyrosine kinase PYK2 and by Ca(2+)/calmodulin-dependent guanine nucleotide exchange factors (GEFs) such as Ras-GRF; however, there is no Ca(2+)-dependent mechanism for direct inactivation. An important advance toward greater understanding of the complex coordination within the Ras-signaling network is the spatio-temporal analysis of signaling events in vivo. Here, we describe the identification of CAPRI (Ca(2+)-promoted Ras inactivator), a Ca(2+)-dependent Ras GTPase-activating protein (GAP) that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular Ca(2+). Analysis of the spatio-temporal dynamics of CAPRI indicates that Ca(2+) regulates the GAP by a fast C2 domain-dependent translocation mechanism. | lld:pubmed |
| pubmed-article:11448776 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11448776 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11448776 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11448776 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11448776 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11448776 | pubmed:issn | 0960-9822 | lld:pubmed |
| pubmed-article:11448776 | pubmed:author | pubmed-author:CullenP JPJ | lld:pubmed |
| pubmed-article:11448776 | pubmed:author | pubmed-author:LockyerP JPJ | lld:pubmed |
| pubmed-article:11448776 | pubmed:author | pubmed-author:KupzigSS | lld:pubmed |
| pubmed-article:11448776 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11448776 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:11448776 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:11448776 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11448776 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11448776 | pubmed:pagination | 981-6 | lld:pubmed |
| pubmed-article:11448776 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11448776 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11448776 | pubmed:articleTitle | CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. | lld:pubmed |
| pubmed-article:11448776 | pubmed:affiliation | Department of Biochemistry, School of Medical Sciences, University of Bristol, BS8 1TD, Bristol, United Kingdom. P.J.Lockyer@bristol.ac.uk | lld:pubmed |
| pubmed-article:11448776 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11448776 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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