| pubmed-article:11447257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11447257 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:11447257 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11447257 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:11447257 | lifeskim:mentions | umls-concept:C0547070 | lld:lifeskim |
| pubmed-article:11447257 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:11447257 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11447257 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:11447257 | pubmed:dateCreated | 2001-7-18 | lld:pubmed |
| pubmed-article:11447257 | pubmed:abstractText | On deletion of the gene encoding the constant region of the T cell antigen receptor (TCR)alpha chain in mature T cells by induced Cre-mediated recombination, the cells lose most of their TCR from the cell surface within 7--10 days, but minute amounts of surface-bound TCR beta chains are retained for long periods of time. In a situation in which cellular influx from the thymus is blocked, TCR-deficient naive T cells decay over time, the decay rates being faster for CD8(+) cells (t(1/2) approximately 16 days) than for CD4(+) cells (t(1/2) approximately 46 days). TCR(+) naïve cells are either maintained (CD8(+)) or decay more slowly (CD4(+); t(1/2) approximately 78 days.) Numbers of TCR-deficient memory T cells decline very slowly (CD8(+) cells; t(1/2) approximately 52 days) or not at all (CD4(+) cells), but at the population level, these cells fail to expand as their TCR(+) counterparts do. Together with earlier data on T cell maintenance in environments lacking appropriate major histocompatibility complex antigens, these data argue against the possibility that spontaneous ligand-independent signaling by the alpha beta TCR contributes significantly to T-cell homeostasis. | lld:pubmed |
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| pubmed-article:11447257 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11447257 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11447257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11447257 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11447257 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11447257 | pubmed:author | pubmed-author:RajewskyKK | lld:pubmed |
| pubmed-article:11447257 | pubmed:author | pubmed-author:KunkelDD | lld:pubmed |
| pubmed-article:11447257 | pubmed:author | pubmed-author:ScheffoldAA | lld:pubmed |
| pubmed-article:11447257 | pubmed:author | pubmed-author:PolicBB | lld:pubmed |
| pubmed-article:11447257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11447257 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:11447257 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11447257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11447257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11447257 | pubmed:pagination | 8744-9 | lld:pubmed |
| pubmed-article:11447257 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
| pubmed-article:11447257 | pubmed:meshHeading | pubmed-meshheading:11447257... | lld:pubmed |
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| pubmed-article:11447257 | pubmed:meshHeading | pubmed-meshheading:11447257... | lld:pubmed |
| pubmed-article:11447257 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11447257 | pubmed:articleTitle | How alpha beta T cells deal with induced TCR alpha ablation. | lld:pubmed |
| pubmed-article:11447257 | pubmed:affiliation | Department of Immunology, Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne, Germany. bojanp@medri.hr | lld:pubmed |
| pubmed-article:11447257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11447257 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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