| pubmed-article:11447188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C0006852 | lld:lifeskim |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C0024262 | lld:lifeskim |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C0007578 | lld:lifeskim |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11447188 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11447188 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11447188 | pubmed:dateCreated | 2001-7-11 | lld:pubmed |
| pubmed-article:11447188 | pubmed:abstractText | Cell-mediated immunity by Th1-type CD4(+) T cells is the predominant host defense mechanism against mucosal candidiasis. However, studies using an estrogen-dependent murine model of vaginal candidiasis have demonstrated little to no change in resident vaginal T cells during infection and no systemic T-cell infiltration despite the presence of Candida-specific systemic Th1-type responses in infected mice. The present study was designed to further investigate these observations by characterizing T-cell activation and cell adhesion molecule expression during primary and secondary C. albicans vaginal infections. While flow cytometry analysis of activation markers showed some evidence for activation of CD3(+) draining lymph node and/or vaginal lymphocytes during both primary and secondary vaginal Candida infection, CD3(+) cells expressing the homing receptors and integrins alpha(4)beta(7), alpha(M290)beta(7), and alpha(4)beta(1) in draining lymph nodes of mice with primary and secondary infections were reduced compared to results for uninfected mice. At the local level, few vaginal lymphocytes expressed integrins, with only minor changes observed during both primary and secondary infections. On the other hand, immunohistochemical analysis of vaginal cell adhesion molecule expression showed increases in mucosal addressin cell adhesion molecule 1 and vascular cell adhesion molecule 1 expression during both primary and secondary infections. Altogether, these data suggest that although the vaginal tissue is permissive to cellular infiltration during a vaginal Candida infection, the reduced numbers of systemic cells expressing the reciprocal cellular adhesion molecules may preempt cellular infiltration, thereby limiting Candida-specific T-cell responses against infection. | lld:pubmed |
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| pubmed-article:11447188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11447188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11447188 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11447188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11447188 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11447188 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:11447188 | pubmed:author | pubmed-author:FidelP LPLJr | lld:pubmed |
| pubmed-article:11447188 | pubmed:author | pubmed-author:ChaibanJJ | lld:pubmed |
| pubmed-article:11447188 | pubmed:author | pubmed-author:WormleyF... | lld:pubmed |
| pubmed-article:11447188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11447188 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:11447188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11447188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11447188 | pubmed:pagination | 5072-9 | lld:pubmed |
| pubmed-article:11447188 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11447188 | pubmed:meshHeading | pubmed-meshheading:11447188... | lld:pubmed |
| pubmed-article:11447188 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11447188 | pubmed:articleTitle | Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis. | lld:pubmed |
| pubmed-article:11447188 | pubmed:affiliation | Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112-1393, USA. | lld:pubmed |
| pubmed-article:11447188 | pubmed:publicationType | Journal Article | lld:pubmed |
