| pubmed-article:11441127 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C0015687 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C0038233 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C1157337 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11441127 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:11441127 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11441127 | pubmed:dateCreated | 2001-7-6 | lld:pubmed |
| pubmed-article:11441127 | pubmed:abstractText | Stearoyl-CoA desaturase (SCD) catalyzes the de novo biosynthesis of oleate and palmitoleate, which are the major fatty acids found in triglycerides, cholesteryl esters, and phospholipids. A high carbohydrate (lipogenic) diet induces lipogenic gene expression by sterol regulatory element binding protein 1 (SREBP-1c)-mediated gene transcription, leading to an increase in the synthesis of triglycerides. The lipogenic diet fed to mice with a null mutation in the SCD1 gene (SCD-/-) fails to induce the synthesis of triglycerides in liver, despite the induction of expression of SREBP-1 and its target genes, fatty acid synthase and glycerol-3-phosphate acyltransferase. The lipogenic diet led to a decrease in the levels of triglyceride, but an increase in the level of cholesteryl esters of saturated fatty acids. Feeding a lipogenic diet supplemented with high levels of oleate to the SCD-/- mice resulted in incorporation of oleate in the liver of SCD-/- mice, but failed to restore triglycerides to the levels in the normal mouse. Triglyceride synthesis, as measured by the incorporation of [(3)H]glycerol, was dramatically reduced in the liver of SCD-/- mouse fed a lipogenic diet compared with the normal mouse. These observations demonstrate that induction of triglyceride synthesis is highly dependent on SCD1 gene expression. | lld:pubmed |
| pubmed-article:11441127 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11441127 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11441127 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11441127 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11441127 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11441127 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:11441127 | pubmed:author | pubmed-author:MiyazakiMM | lld:pubmed |
| pubmed-article:11441127 | pubmed:author | pubmed-author:KimY CYC | lld:pubmed |
| pubmed-article:11441127 | pubmed:author | pubmed-author:NtambiJ MJM | lld:pubmed |
| pubmed-article:11441127 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11441127 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:11441127 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11441127 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11441127 | pubmed:pagination | 1018-24 | lld:pubmed |
| pubmed-article:11441127 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11441127 | pubmed:meshHeading | pubmed-meshheading:11441127... | lld:pubmed |
| pubmed-article:11441127 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11441127 | pubmed:articleTitle | A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. | lld:pubmed |
| pubmed-article:11441127 | pubmed:affiliation | Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA. | lld:pubmed |
| pubmed-article:11441127 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11441127 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:20249 | entrezgene:pubmed | pubmed-article:11441127 | lld:entrezgene |
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